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A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism
The ABO locus in humans is characterized by elevated heterozygosity and very similar allele frequencies among populations scattered across the globe. Using knowledge of ABO protein function, we generated a simple model of asymmetric negative frequency dependent selection and genetic drift to explain...
Autores principales: | Villanea, Fernando A., Safi, Kristin N., Busch, Jeremiah W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422588/ https://www.ncbi.nlm.nih.gov/pubmed/25946124 http://dx.doi.org/10.1371/journal.pone.0125003 |
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