Epinephrine reversed high-concentration bupivacaine- induced inhibition of calcium channels and transient outward potassium current channels, but not on sodium channel in ventricular myocytes of rats

BACKGROUND: Epinephrine is a first-line drug for cardiopulmonary resuscitation, but its efficacy in the treatment of bupivacaine-induced cardiac toxicity is still in question. We hypothesized that epinephrine can reverse cardiac inhibition of bupivacaine by modulating ion flows through the ventricul...

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Detalles Bibliográficos
Autores principales: Liu, Fuli, Wu, Bingjing, Du, Yongjun, Wu, Yiquan, Chen, Hongfei, Xia, Fangfang, Jin, Zhousheng, Xu, Xuzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422592/
https://www.ncbi.nlm.nih.gov/pubmed/25924894
http://dx.doi.org/10.1186/s12871-015-0049-1

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