Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation

The folding and unfolding of protein domains is an apparently cooperative process, but transient intermediates have been detected in some cases. Such (un)folding intermediates are challenging to investigate structurally as they are typically not long-lived and their role in the (un)folding reaction...

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Detalles Bibliográficos
Autores principales: Nasedkin, Alexandr, Marcellini, Moreno, Religa, Tomasz L., Freund, Stefan M., Menzel, Andreas, Fersht, Alan R., Jemth, Per, van der Spoel, David, Davidsson, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422743/
https://www.ncbi.nlm.nih.gov/pubmed/25946337
http://dx.doi.org/10.1371/journal.pone.0125662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422743/
https://www.ncbi.nlm.nih.gov/pubmed/25946337
http://dx.doi.org/10.1371/journal.pone.0125662

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