Tenascin-C and integrins in cancer

Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenc...

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Detalles Bibliográficos
Autores principales: Yoshida, Toshimichi, Akatsuka, Tatsuya, Imanaka-Yoshida, Kyoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422796/
https://www.ncbi.nlm.nih.gov/pubmed/25793576
http://dx.doi.org/10.1080/19336918.2015.1008332
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author Yoshida, Toshimichi
Akatsuka, Tatsuya
Imanaka-Yoshida, Kyoko
author_facet Yoshida, Toshimichi
Akatsuka, Tatsuya
Imanaka-Yoshida, Kyoko
author_sort Yoshida, Toshimichi
collection PubMed
description Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.
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spelling pubmed-44227962016-02-03 Tenascin-C and integrins in cancer Yoshida, Toshimichi Akatsuka, Tatsuya Imanaka-Yoshida, Kyoko Cell Adh Migr Reviews Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed. Taylor & Francis 2015-03-20 /pmc/articles/PMC4422796/ /pubmed/25793576 http://dx.doi.org/10.1080/19336918.2015.1008332 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Reviews
Yoshida, Toshimichi
Akatsuka, Tatsuya
Imanaka-Yoshida, Kyoko
Tenascin-C and integrins in cancer
title Tenascin-C and integrins in cancer
title_full Tenascin-C and integrins in cancer
title_fullStr Tenascin-C and integrins in cancer
title_full_unstemmed Tenascin-C and integrins in cancer
title_short Tenascin-C and integrins in cancer
title_sort tenascin-c and integrins in cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422796/
https://www.ncbi.nlm.nih.gov/pubmed/25793576
http://dx.doi.org/10.1080/19336918.2015.1008332
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