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Tenascin-C: Form versus function

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecu...

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Detalles Bibliográficos
Autores principales: Giblin, Sean P, Midwood, Kim S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422809/
https://www.ncbi.nlm.nih.gov/pubmed/25482829
http://dx.doi.org/10.4161/19336918.2014.987587
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author Giblin, Sean P
Midwood, Kim S
author_facet Giblin, Sean P
Midwood, Kim S
author_sort Giblin, Sean P
collection PubMed
description Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.
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spelling pubmed-44228092015-12-06 Tenascin-C: Form versus function Giblin, Sean P Midwood, Kim S Cell Adh Migr Reviews Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function. Taylor & Francis 2014-12-06 /pmc/articles/PMC4422809/ /pubmed/25482829 http://dx.doi.org/10.4161/19336918.2014.987587 Text en © 2015 The Author(s). Published with License by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Reviews
Giblin, Sean P
Midwood, Kim S
Tenascin-C: Form versus function
title Tenascin-C: Form versus function
title_full Tenascin-C: Form versus function
title_fullStr Tenascin-C: Form versus function
title_full_unstemmed Tenascin-C: Form versus function
title_short Tenascin-C: Form versus function
title_sort tenascin-c: form versus function
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422809/
https://www.ncbi.nlm.nih.gov/pubmed/25482829
http://dx.doi.org/10.4161/19336918.2014.987587
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