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Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients

PURPOSE: Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI....

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Autores principales: Kym, Dohern, Cho, Yong-Suk, Yoon, Jaechul, Yim, Haejun, Yang, Hyeong-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Surgical Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422882/
https://www.ncbi.nlm.nih.gov/pubmed/25960992
http://dx.doi.org/10.4174/astr.2015.88.5.281
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author Kym, Dohern
Cho, Yong-Suk
Yoon, Jaechul
Yim, Haejun
Yang, Hyeong-Tae
author_facet Kym, Dohern
Cho, Yong-Suk
Yoon, Jaechul
Yim, Haejun
Yang, Hyeong-Tae
author_sort Kym, Dohern
collection PubMed
description PURPOSE: Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI. METHODS: A total of 85 patients who were admitted to the burn intensive care unit from June 2012 to July 2013 were included in this prospective cohort study. Ten biomarkers (blood urea nitrogen, serum creatinine, urine creatinine, cystatin C, cystatin C glomerular filtration rate, AST, lacate dehydrogenase [LD], creatine kinase, lactic acid, and myoglobin) were obtained at time of admission and evaluated as diagnostic biomarkers to predicting AKI and early AKI. RESULTS: Out of 85 patients, 35 patients were dead and overall mortality was 41.2%. The mean age was 49.4 years and mean percentage of total body surface area was 53.2%. Area under the curve (AUC) of receiver operating characteristic curve of biomarkers on predicting AKI were 0.746, 0.718, and 0.717 in LD, lactic acid, and serum creatinine, respectively. AUC of cystatin C predicting AKI was much lower at 0.555. AUC of biomarkers on predicting early AKI were 0.833, 0.816, 0.790, and 0.759 in LD, serum creatinine, AST, and serum myoglobin. CONCLUSION: LD, lactic acid and serum creatinine were acceptable as diagnostic biomarkers of AKI and LD, serum creatinine, AST, and serum myoglobin were reasonable as diagnostic biomarkers of early AKI. However, cystatin C was an unfavorable biomarker in major burn patients.
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spelling pubmed-44228822015-05-08 Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients Kym, Dohern Cho, Yong-Suk Yoon, Jaechul Yim, Haejun Yang, Hyeong-Tae Ann Surg Treat Res Original Article PURPOSE: Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI. METHODS: A total of 85 patients who were admitted to the burn intensive care unit from June 2012 to July 2013 were included in this prospective cohort study. Ten biomarkers (blood urea nitrogen, serum creatinine, urine creatinine, cystatin C, cystatin C glomerular filtration rate, AST, lacate dehydrogenase [LD], creatine kinase, lactic acid, and myoglobin) were obtained at time of admission and evaluated as diagnostic biomarkers to predicting AKI and early AKI. RESULTS: Out of 85 patients, 35 patients were dead and overall mortality was 41.2%. The mean age was 49.4 years and mean percentage of total body surface area was 53.2%. Area under the curve (AUC) of receiver operating characteristic curve of biomarkers on predicting AKI were 0.746, 0.718, and 0.717 in LD, lactic acid, and serum creatinine, respectively. AUC of cystatin C predicting AKI was much lower at 0.555. AUC of biomarkers on predicting early AKI were 0.833, 0.816, 0.790, and 0.759 in LD, serum creatinine, AST, and serum myoglobin. CONCLUSION: LD, lactic acid and serum creatinine were acceptable as diagnostic biomarkers of AKI and LD, serum creatinine, AST, and serum myoglobin were reasonable as diagnostic biomarkers of early AKI. However, cystatin C was an unfavorable biomarker in major burn patients. The Korean Surgical Society 2015-05 2015-04-30 /pmc/articles/PMC4422882/ /pubmed/25960992 http://dx.doi.org/10.4174/astr.2015.88.5.281 Text en Copyright © 2015, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0/ Annals of Surgical Treatment and Research is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kym, Dohern
Cho, Yong-Suk
Yoon, Jaechul
Yim, Haejun
Yang, Hyeong-Tae
Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title_full Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title_fullStr Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title_full_unstemmed Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title_short Evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
title_sort evaluation of diagnostic biomarkers for acute kidney injury in major burn patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422882/
https://www.ncbi.nlm.nih.gov/pubmed/25960992
http://dx.doi.org/10.4174/astr.2015.88.5.281
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