Cargando…
Mechanochemical Symmetry Breaking in Hydra Aggregates
Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we devel...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423050/ https://www.ncbi.nlm.nih.gov/pubmed/25954896 http://dx.doi.org/10.1016/j.bpj.2015.03.033 |
_version_ | 1782370143896076288 |
---|---|
author | Mercker, Moritz Köthe, Alexandra Marciniak-Czochra, Anna |
author_facet | Mercker, Moritz Köthe, Alexandra Marciniak-Czochra, Anna |
author_sort | Mercker, Moritz |
collection | PubMed |
description | Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra. |
format | Online Article Text |
id | pubmed-4423050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Biophysical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-44230502015-07-10 Mechanochemical Symmetry Breaking in Hydra Aggregates Mercker, Moritz Köthe, Alexandra Marciniak-Czochra, Anna Biophys J Systems Biophysics Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra. The Biophysical Society 2015-05-05 /pmc/articles/PMC4423050/ /pubmed/25954896 http://dx.doi.org/10.1016/j.bpj.2015.03.033 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Systems Biophysics Mercker, Moritz Köthe, Alexandra Marciniak-Czochra, Anna Mechanochemical Symmetry Breaking in Hydra Aggregates |
title | Mechanochemical Symmetry Breaking in Hydra Aggregates |
title_full | Mechanochemical Symmetry Breaking in Hydra Aggregates |
title_fullStr | Mechanochemical Symmetry Breaking in Hydra Aggregates |
title_full_unstemmed | Mechanochemical Symmetry Breaking in Hydra Aggregates |
title_short | Mechanochemical Symmetry Breaking in Hydra Aggregates |
title_sort | mechanochemical symmetry breaking in hydra aggregates |
topic | Systems Biophysics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423050/ https://www.ncbi.nlm.nih.gov/pubmed/25954896 http://dx.doi.org/10.1016/j.bpj.2015.03.033 |
work_keys_str_mv | AT merckermoritz mechanochemicalsymmetrybreakinginhydraaggregates AT kothealexandra mechanochemicalsymmetrybreakinginhydraaggregates AT marciniakczochraanna mechanochemicalsymmetrybreakinginhydraaggregates |