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Mechanochemical Symmetry Breaking in Hydra Aggregates

Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we devel...

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Detalles Bibliográficos
Autores principales: Mercker, Moritz, Köthe, Alexandra, Marciniak-Czochra, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423050/
https://www.ncbi.nlm.nih.gov/pubmed/25954896
http://dx.doi.org/10.1016/j.bpj.2015.03.033
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author Mercker, Moritz
Köthe, Alexandra
Marciniak-Czochra, Anna
author_facet Mercker, Moritz
Köthe, Alexandra
Marciniak-Czochra, Anna
author_sort Mercker, Moritz
collection PubMed
description Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra.
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spelling pubmed-44230502015-07-10 Mechanochemical Symmetry Breaking in Hydra Aggregates Mercker, Moritz Köthe, Alexandra Marciniak-Czochra, Anna Biophys J Systems Biophysics Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra. The Biophysical Society 2015-05-05 /pmc/articles/PMC4423050/ /pubmed/25954896 http://dx.doi.org/10.1016/j.bpj.2015.03.033 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Systems Biophysics
Mercker, Moritz
Köthe, Alexandra
Marciniak-Czochra, Anna
Mechanochemical Symmetry Breaking in Hydra Aggregates
title Mechanochemical Symmetry Breaking in Hydra Aggregates
title_full Mechanochemical Symmetry Breaking in Hydra Aggregates
title_fullStr Mechanochemical Symmetry Breaking in Hydra Aggregates
title_full_unstemmed Mechanochemical Symmetry Breaking in Hydra Aggregates
title_short Mechanochemical Symmetry Breaking in Hydra Aggregates
title_sort mechanochemical symmetry breaking in hydra aggregates
topic Systems Biophysics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423050/
https://www.ncbi.nlm.nih.gov/pubmed/25954896
http://dx.doi.org/10.1016/j.bpj.2015.03.033
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