ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

F-box and WD repeat domain-containing 7 (FBW7) is the substrate recognition component of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex and functions as a major tumor suppressor by targeting various oncoproteins for degradation. Genomic deletion or mutation of FBW7 has frequently been identified...

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Detalles Bibliográficos
Autores principales: Ji, Shunrong, Qin, Yi, Shi, Si, Liu, Xiangyuan, Hu, Hongli, Zhou, Hu, Gao, Jing, Zhang, Bo, Xu, Wenyan, Liu, Jiang, Liang, Dingkong, Liu, Liang, Liu, Chen, Long, Jiang, Zhou, Haijun, Chiao, Paul J, Xu, Jin, Ni, Quanxing, Gao, Daming, Yu, Xianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423074/
https://www.ncbi.nlm.nih.gov/pubmed/25753158
http://dx.doi.org/10.1038/cr.2015.30

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