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Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model
BACKGROUND: The present study was designed to study anxiolytic property of methanolic extracts of Urtica urens; an important and commonly used for its medicinal properties belongs to urticaceae family. METHODS: The anxiolytic activity was evaluated with the adult mice by hole board test, and the lig...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423131/ https://www.ncbi.nlm.nih.gov/pubmed/25902868 http://dx.doi.org/10.1186/s12993-015-0063-y |
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author | Doukkali, Zouhra Taghzouti, Khalid Bouidida, EL Houcine Nadjmouddine, Mohamed Cherrah, Yahya Alaoui, Katim |
author_facet | Doukkali, Zouhra Taghzouti, Khalid Bouidida, EL Houcine Nadjmouddine, Mohamed Cherrah, Yahya Alaoui, Katim |
author_sort | Doukkali, Zouhra |
collection | PubMed |
description | BACKGROUND: The present study was designed to study anxiolytic property of methanolic extracts of Urtica urens; an important and commonly used for its medicinal properties belongs to urticaceae family. METHODS: The anxiolytic activity was evaluated with the adult mice by hole board test, and the light–dark box test, and motor coordination with the rota rod test. The efficacy of the plant extract (100–400 mg/kg) was compared with the standard anxiolytic drug diazepam (1 mg/kg i.p.) RESULTS: The extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other. Performance on the rota rod was unaffected. In the hole board test, the extract significantly increased both head-dip counts and head-dip duration. Urtica urens, in contrast to diazepam, had no effect on locomotion. CONCLUSIONS: These results provides support for anxiolytic activity of Urtica urens, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Urtica urens relative to diazepam. |
format | Online Article Text |
id | pubmed-4423131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44231312015-05-08 Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model Doukkali, Zouhra Taghzouti, Khalid Bouidida, EL Houcine Nadjmouddine, Mohamed Cherrah, Yahya Alaoui, Katim Behav Brain Funct Research BACKGROUND: The present study was designed to study anxiolytic property of methanolic extracts of Urtica urens; an important and commonly used for its medicinal properties belongs to urticaceae family. METHODS: The anxiolytic activity was evaluated with the adult mice by hole board test, and the light–dark box test, and motor coordination with the rota rod test. The efficacy of the plant extract (100–400 mg/kg) was compared with the standard anxiolytic drug diazepam (1 mg/kg i.p.) RESULTS: The extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other. Performance on the rota rod was unaffected. In the hole board test, the extract significantly increased both head-dip counts and head-dip duration. Urtica urens, in contrast to diazepam, had no effect on locomotion. CONCLUSIONS: These results provides support for anxiolytic activity of Urtica urens, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Urtica urens relative to diazepam. BioMed Central 2015-04-24 /pmc/articles/PMC4423131/ /pubmed/25902868 http://dx.doi.org/10.1186/s12993-015-0063-y Text en © Doukkali et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Doukkali, Zouhra Taghzouti, Khalid Bouidida, EL Houcine Nadjmouddine, Mohamed Cherrah, Yahya Alaoui, Katim Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title | Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title_full | Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title_fullStr | Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title_full_unstemmed | Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title_short | Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model |
title_sort | evaluation of anxiolytic activity of methanolic extract of urtica urens in a mice model |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423131/ https://www.ncbi.nlm.nih.gov/pubmed/25902868 http://dx.doi.org/10.1186/s12993-015-0063-y |
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