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Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives

From neurophenomenological perspectives, schizophrenia has been conceptualized as “a disorder with heterogeneous manifestations that can be integrally understood to involve fundamental perturbations in consciousness”. While these theoretical constructs based on consciousness facilitate understanding...

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Autor principal: Venkatasubramanian, Ganesan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean College of Neuropsychopharmacology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423156/
https://www.ncbi.nlm.nih.gov/pubmed/25912536
http://dx.doi.org/10.9758/cpn.2015.13.1.36
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author Venkatasubramanian, Ganesan
author_facet Venkatasubramanian, Ganesan
author_sort Venkatasubramanian, Ganesan
collection PubMed
description From neurophenomenological perspectives, schizophrenia has been conceptualized as “a disorder with heterogeneous manifestations that can be integrally understood to involve fundamental perturbations in consciousness”. While these theoretical constructs based on consciousness facilitate understanding the ‘gestalt’ of schizophrenia, systematic research to unravel translational implications of these models is warranted. To address this, one needs to begin with exploration of plausible biological underpinnings of “perturbed consciousness” in schizophrenia. In this context, an attractive proposition to understand the biology of consciousness is “the orchestrated object reduction (Orch-OR) theory” which invokes quantum processes in the microtubules of neurons. The Orch-OR model is particularly important for understanding schizophrenia especially due to the shared ‘scaffold’ of microtubules. The initial sections of this review focus on the compelling evidence to support the view that “schizophrenia is a disorder of consciousness” through critical summary of the studies that have demonstrated self-abnormalities, aberrant time perception as well as dysfunctional intentional binding in this disorder. Subsequently, these findings are linked with ‘Orch-OR theory’ through the research evidence for aberrant neural oscillations as well as microtubule abnormalities observed in schizophrenia. Further sections emphasize the applicability and translational implications of Orch-OR theory in the context of schizophrenia and elucidate the relevance of quantum biology to understand the origins of this puzzling disorder as “fundamental disturbances in consciousness”.
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spelling pubmed-44231562015-05-08 Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives Venkatasubramanian, Ganesan Clin Psychopharmacol Neurosci Review From neurophenomenological perspectives, schizophrenia has been conceptualized as “a disorder with heterogeneous manifestations that can be integrally understood to involve fundamental perturbations in consciousness”. While these theoretical constructs based on consciousness facilitate understanding the ‘gestalt’ of schizophrenia, systematic research to unravel translational implications of these models is warranted. To address this, one needs to begin with exploration of plausible biological underpinnings of “perturbed consciousness” in schizophrenia. In this context, an attractive proposition to understand the biology of consciousness is “the orchestrated object reduction (Orch-OR) theory” which invokes quantum processes in the microtubules of neurons. The Orch-OR model is particularly important for understanding schizophrenia especially due to the shared ‘scaffold’ of microtubules. The initial sections of this review focus on the compelling evidence to support the view that “schizophrenia is a disorder of consciousness” through critical summary of the studies that have demonstrated self-abnormalities, aberrant time perception as well as dysfunctional intentional binding in this disorder. Subsequently, these findings are linked with ‘Orch-OR theory’ through the research evidence for aberrant neural oscillations as well as microtubule abnormalities observed in schizophrenia. Further sections emphasize the applicability and translational implications of Orch-OR theory in the context of schizophrenia and elucidate the relevance of quantum biology to understand the origins of this puzzling disorder as “fundamental disturbances in consciousness”. Korean College of Neuropsychopharmacology 2015-04 2015-04-30 /pmc/articles/PMC4423156/ /pubmed/25912536 http://dx.doi.org/10.9758/cpn.2015.13.1.36 Text en Copyright © 2015, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Venkatasubramanian, Ganesan
Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title_full Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title_fullStr Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title_full_unstemmed Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title_short Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives
title_sort understanding schizophrenia as a disorder of consciousness: biological correlates and translational implications from quantum theory perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423156/
https://www.ncbi.nlm.nih.gov/pubmed/25912536
http://dx.doi.org/10.9758/cpn.2015.13.1.36
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