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Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2

We report the crystal structure of a 40mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids. The L-oligonuc...

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Detalles Bibliográficos
Autores principales:	Oberthür, Dominik, Achenbach, John, Gabdulkhakov, Azat, Buchner, Klaus, Maasch, Christian, Falke, Sven, Rehders, Dirk, Klussmann, Sven, Betzel, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423205/ https://www.ncbi.nlm.nih.gov/pubmed/25901662 http://dx.doi.org/10.1038/ncomms7923

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