Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive ‘macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors,...

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Detalles Bibliográficos
Autores principales: Papaspyridonos, Marianna, Matei, Irina, Huang, Yujie, do Rosario Andre, Maria, Brazier-Mitouart, Helene, Waite, Janelle C., Chan, April S., Kalter, Julie, Ramos, Ilyssa, Wu, Qi, Williams, Caitlin, Wolchok, Jedd D., Chapman, Paul B., Peinado, Hector, Anandasabapathy, Niroshana, Ocean, Allyson J., Kaplan, Rosandra N., Greenfield, Jeffrey P., Bromberg, Jacqueline, Skokos, Dimitris, Lyden, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423225/
https://www.ncbi.nlm.nih.gov/pubmed/25924227
http://dx.doi.org/10.1038/ncomms7840

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