Cargando…

Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution

Endoscopic ultrasonography with fine needle infusion (EUS-FNI) of alcohol is the most reported method for EUS-guided tumor ablation. Several studies have reported successful EUS-guided ablation of pancreatic neuroendocrine tumors. However, these tumors have been relatively small (< 3 cm). In this...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathers, Bradley W., Harvey, Harold A., Dye, Charles E., Dougherty-Hamod, Brandy, Moyer, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: © Georg Thieme Verlag KG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423311/
https://www.ncbi.nlm.nih.gov/pubmed/26135103
http://dx.doi.org/10.1055/s-0034-1377612
_version_ 1782370193353211904
author Mathers, Bradley W.
Harvey, Harold A.
Dye, Charles E.
Dougherty-Hamod, Brandy
Moyer, Matthew T.
author_facet Mathers, Bradley W.
Harvey, Harold A.
Dye, Charles E.
Dougherty-Hamod, Brandy
Moyer, Matthew T.
author_sort Mathers, Bradley W.
collection PubMed
description Endoscopic ultrasonography with fine needle infusion (EUS-FNI) of alcohol is the most reported method for EUS-guided tumor ablation. Several studies have reported successful EUS-guided ablation of pancreatic neuroendocrine tumors. However, these tumors have been relatively small (< 3 cm). In this report, a 50-year-old man with a metastatic carcinoid tumor with a large porta hepatis mass was referred to our clinic for EUS-guided ethanol ablation. After two separate EUS-FNI ablations, there was a 36 % reduction in tumor size (9.0 × 11.4 cm to 6.7 × 9.8 cm) with associated tumor lysis syndrome. Chromogranin A levels decreased from 460 to 132 ng/mL. The patient reported complete resolution of abdominal pain within 2 weeks, but only mild improvement in flushing and diarrhea. In conclusion, large metastatic neuroendocrine tumors can be successfully treated with EUS-guided ethanol ablation. Evidence-based guidelines are needed with regard to the appropriate volume of ethanol injected in EUS-guided ablation to promote the efficacy and safety of this emerging procedure.
format Online
Article
Text
id pubmed-4423311
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher © Georg Thieme Verlag KG
record_format MEDLINE/PubMed
spelling pubmed-44233112015-06-23 Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution Mathers, Bradley W. Harvey, Harold A. Dye, Charles E. Dougherty-Hamod, Brandy Moyer, Matthew T. Endosc Int Open Article Endoscopic ultrasonography with fine needle infusion (EUS-FNI) of alcohol is the most reported method for EUS-guided tumor ablation. Several studies have reported successful EUS-guided ablation of pancreatic neuroendocrine tumors. However, these tumors have been relatively small (< 3 cm). In this report, a 50-year-old man with a metastatic carcinoid tumor with a large porta hepatis mass was referred to our clinic for EUS-guided ethanol ablation. After two separate EUS-FNI ablations, there was a 36 % reduction in tumor size (9.0 × 11.4 cm to 6.7 × 9.8 cm) with associated tumor lysis syndrome. Chromogranin A levels decreased from 460 to 132 ng/mL. The patient reported complete resolution of abdominal pain within 2 weeks, but only mild improvement in flushing and diarrhea. In conclusion, large metastatic neuroendocrine tumors can be successfully treated with EUS-guided ethanol ablation. Evidence-based guidelines are needed with regard to the appropriate volume of ethanol injected in EUS-guided ablation to promote the efficacy and safety of this emerging procedure. © Georg Thieme Verlag KG 2014-12 2014-09-19 /pmc/articles/PMC4423311/ /pubmed/26135103 http://dx.doi.org/10.1055/s-0034-1377612 Text en © Thieme Medical Publishers
spellingShingle Article
Mathers, Bradley W.
Harvey, Harold A.
Dye, Charles E.
Dougherty-Hamod, Brandy
Moyer, Matthew T.
Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title_full Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title_fullStr Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title_full_unstemmed Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title_short Endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
title_sort endoscopic ultrasound-guided ethanol ablation of a large metastatic carcinoid tumor: success with a note of caution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423311/
https://www.ncbi.nlm.nih.gov/pubmed/26135103
http://dx.doi.org/10.1055/s-0034-1377612
work_keys_str_mv AT mathersbradleyw endoscopicultrasoundguidedethanolablationofalargemetastaticcarcinoidtumorsuccesswithanoteofcaution
AT harveyharolda endoscopicultrasoundguidedethanolablationofalargemetastaticcarcinoidtumorsuccesswithanoteofcaution
AT dyecharlese endoscopicultrasoundguidedethanolablationofalargemetastaticcarcinoidtumorsuccesswithanoteofcaution
AT doughertyhamodbrandy endoscopicultrasoundguidedethanolablationofalargemetastaticcarcinoidtumorsuccesswithanoteofcaution
AT moyermatthewt endoscopicultrasoundguidedethanolablationofalargemetastaticcarcinoidtumorsuccesswithanoteofcaution