Cargando…
A novel and rapid method for obtaining high titre intact prion strains from mammalian brain
Mammalian prions exist as multiple strains which produce characteristic and highly reproducible phenotypes in defined hosts. How this strain diversity is encoded by a protein-only agent remains one of the most interesting and challenging questions in biology with wide relevance to understanding othe...
Autores principales: | Wenborn, Adam, Terry, Cassandra, Gros, Nathalie, Joiner, Susan, D’Castro, Laura, Panico, Silvia, Sells, Jessica, Cronier, Sabrina, Linehan, Jacqueline M., Brandner, Sebastian, Saibil, Helen R., Collinge, John, Wadsworth, Jonathan D. F. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423448/ https://www.ncbi.nlm.nih.gov/pubmed/25950908 http://dx.doi.org/10.1038/srep10062 |
Ejemplares similares
-
Ex vivo mammalian prions are formed of paired double helical prion protein fibrils
por: Terry, Cassandra, et al.
Publicado: (2016) -
Isolation of Proteinase K-Sensitive Prions Using Pronase E and Phosphotungstic Acid
por: D'Castro, Laura, et al.
Publicado: (2010) -
Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro
por: Terry, Cassandra, et al.
Publicado: (2019) -
A structural basis for prion strain diversity
por: Manka, Szymon W., et al.
Publicado: (2023) -
Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked
por: Sandberg, Malin K., et al.
Publicado: (2014)