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Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts

Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus an...

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Autores principales: Levy, Roger A., dos Santos, Flavia Cunha, de Jesús, Guilherme R., de Jesús, Nilson R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423468/
https://www.ncbi.nlm.nih.gov/pubmed/25999948
http://dx.doi.org/10.3389/fimmu.2015.00205
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author Levy, Roger A.
dos Santos, Flavia Cunha
de Jesús, Guilherme R.
de Jesús, Nilson R.
author_facet Levy, Roger A.
dos Santos, Flavia Cunha
de Jesús, Guilherme R.
de Jesús, Nilson R.
author_sort Levy, Roger A.
collection PubMed
description Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent early miscarriages, pre-eclampsia, and placental insufficiency, but does not seem to influence infertility. High quality scientific data to support these associations, however, are lacking, and controversies arise about the definition of positive aPL (low vs medium-high titers) or even the definition of the adverse events. This review discusses APS classification criteria and the current debate about it.
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spelling pubmed-44234682015-05-21 Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts Levy, Roger A. dos Santos, Flavia Cunha de Jesús, Guilherme R. de Jesús, Nilson R. Front Immunol Immunology Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent early miscarriages, pre-eclampsia, and placental insufficiency, but does not seem to influence infertility. High quality scientific data to support these associations, however, are lacking, and controversies arise about the definition of positive aPL (low vs medium-high titers) or even the definition of the adverse events. This review discusses APS classification criteria and the current debate about it. Frontiers Media S.A. 2015-05-07 /pmc/articles/PMC4423468/ /pubmed/25999948 http://dx.doi.org/10.3389/fimmu.2015.00205 Text en Copyright © 2015 Levy, dos Santos, de Jesús and de Jesús. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Levy, Roger A.
dos Santos, Flavia Cunha
de Jesús, Guilherme R.
de Jesús, Nilson R.
Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title_full Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title_fullStr Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title_full_unstemmed Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title_short Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
title_sort antiphospholipid antibodies and antiphospholipid syndrome during pregnancy: diagnostic concepts
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423468/
https://www.ncbi.nlm.nih.gov/pubmed/25999948
http://dx.doi.org/10.3389/fimmu.2015.00205
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