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Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts
Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus an...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423468/ https://www.ncbi.nlm.nih.gov/pubmed/25999948 http://dx.doi.org/10.3389/fimmu.2015.00205 |
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author | Levy, Roger A. dos Santos, Flavia Cunha de Jesús, Guilherme R. de Jesús, Nilson R. |
author_facet | Levy, Roger A. dos Santos, Flavia Cunha de Jesús, Guilherme R. de Jesús, Nilson R. |
author_sort | Levy, Roger A. |
collection | PubMed |
description | Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent early miscarriages, pre-eclampsia, and placental insufficiency, but does not seem to influence infertility. High quality scientific data to support these associations, however, are lacking, and controversies arise about the definition of positive aPL (low vs medium-high titers) or even the definition of the adverse events. This review discusses APS classification criteria and the current debate about it. |
format | Online Article Text |
id | pubmed-4423468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44234682015-05-21 Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts Levy, Roger A. dos Santos, Flavia Cunha de Jesús, Guilherme R. de Jesús, Nilson R. Front Immunol Immunology Antiphospholipid syndrome (APS) comprises of a wide spectrum of clinical and obstetric manifestations linked to the presence of antiphospholipid antibodies (aPL). APS was described in the context of lupus, and later as an isolated syndrome or primary APS. The presence of aPL, especially the lupus anticoagulant test, is associated with adverse pregnancy outcomes, such as fetal death, recurrent early miscarriages, pre-eclampsia, and placental insufficiency, but does not seem to influence infertility. High quality scientific data to support these associations, however, are lacking, and controversies arise about the definition of positive aPL (low vs medium-high titers) or even the definition of the adverse events. This review discusses APS classification criteria and the current debate about it. Frontiers Media S.A. 2015-05-07 /pmc/articles/PMC4423468/ /pubmed/25999948 http://dx.doi.org/10.3389/fimmu.2015.00205 Text en Copyright © 2015 Levy, dos Santos, de Jesús and de Jesús. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Levy, Roger A. dos Santos, Flavia Cunha de Jesús, Guilherme R. de Jesús, Nilson R. Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title | Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title_full | Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title_fullStr | Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title_full_unstemmed | Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title_short | Antiphospholipid Antibodies and Antiphospholipid Syndrome during Pregnancy: Diagnostic Concepts |
title_sort | antiphospholipid antibodies and antiphospholipid syndrome during pregnancy: diagnostic concepts |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423468/ https://www.ncbi.nlm.nih.gov/pubmed/25999948 http://dx.doi.org/10.3389/fimmu.2015.00205 |
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