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Getting older can be exhausting
Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423769/ https://www.ncbi.nlm.nih.gov/pubmed/25184737 http://dx.doi.org/10.1186/s13054-014-0465-5 |
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author | Mittal, Rohit Ford, Mandy L Coopersmith, Craig M |
author_facet | Mittal, Rohit Ford, Mandy L Coopersmith, Craig M |
author_sort | Mittal, Rohit |
collection | PubMed |
description | Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission. |
format | Online Article Text |
id | pubmed-4423769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44237692015-05-08 Getting older can be exhausting Mittal, Rohit Ford, Mandy L Coopersmith, Craig M Crit Care Commentary Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission. BioMed Central 2014-07-29 2014 /pmc/articles/PMC4423769/ /pubmed/25184737 http://dx.doi.org/10.1186/s13054-014-0465-5 Text en © Mittal et al., licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Mittal, Rohit Ford, Mandy L Coopersmith, Craig M Getting older can be exhausting |
title | Getting older can be exhausting |
title_full | Getting older can be exhausting |
title_fullStr | Getting older can be exhausting |
title_full_unstemmed | Getting older can be exhausting |
title_short | Getting older can be exhausting |
title_sort | getting older can be exhausting |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423769/ https://www.ncbi.nlm.nih.gov/pubmed/25184737 http://dx.doi.org/10.1186/s13054-014-0465-5 |
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