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An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis
Large genome-wide association studies have reported hundreds of genetic markers associated with lipid levels. However, the discovery and estimated effect of variants at these loci, derived from samples of exclusively European descent, may not generalize to the majority of the world populations. We e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423846/ https://www.ncbi.nlm.nih.gov/pubmed/25951326 http://dx.doi.org/10.1371/journal.pone.0126361 |
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author | Johnson, Lucia Zhu, Jonathan Scott, Erick R. Wineinger, Nathan E. |
author_facet | Johnson, Lucia Zhu, Jonathan Scott, Erick R. Wineinger, Nathan E. |
author_sort | Johnson, Lucia |
collection | PubMed |
description | Large genome-wide association studies have reported hundreds of genetic markers associated with lipid levels. However, the discovery and estimated effect of variants at these loci, derived from samples of exclusively European descent, may not generalize to the majority of the world populations. We examined the collective strength of association among these loci in a diverse set of U.S. populations from the Multi-Ethnic Study of Atherosclerosis. We constructed a genetic risk score for each lipid outcome based on previously identified lipid-associated genetic markers, and examined the relationship between the genetic risk scores and corresponding outcomes. We discover this relationship was often moderated by race/ethnicity. Our findings provide insight into the generalizability and predictive utility of large sample size meta-analyses results when leveraging data from a single population. We hope these findings will encourage researchers to investigate genetic susceptibility in more diverse populations and explore the source of such discrepancies. Until then, we caution clinicians, genetic counselors, and genetic testing consumers when interpreting genetic data on complex traits. |
format | Online Article Text |
id | pubmed-4423846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44238462015-05-13 An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis Johnson, Lucia Zhu, Jonathan Scott, Erick R. Wineinger, Nathan E. PLoS One Research Article Large genome-wide association studies have reported hundreds of genetic markers associated with lipid levels. However, the discovery and estimated effect of variants at these loci, derived from samples of exclusively European descent, may not generalize to the majority of the world populations. We examined the collective strength of association among these loci in a diverse set of U.S. populations from the Multi-Ethnic Study of Atherosclerosis. We constructed a genetic risk score for each lipid outcome based on previously identified lipid-associated genetic markers, and examined the relationship between the genetic risk scores and corresponding outcomes. We discover this relationship was often moderated by race/ethnicity. Our findings provide insight into the generalizability and predictive utility of large sample size meta-analyses results when leveraging data from a single population. We hope these findings will encourage researchers to investigate genetic susceptibility in more diverse populations and explore the source of such discrepancies. Until then, we caution clinicians, genetic counselors, and genetic testing consumers when interpreting genetic data on complex traits. Public Library of Science 2015-05-07 /pmc/articles/PMC4423846/ /pubmed/25951326 http://dx.doi.org/10.1371/journal.pone.0126361 Text en © 2015 Johnson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Johnson, Lucia Zhu, Jonathan Scott, Erick R. Wineinger, Nathan E. An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title | An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title_full | An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title_fullStr | An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title_full_unstemmed | An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title_short | An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis |
title_sort | examination of the relationship between lipid levels and associated genetic markers across racial/ethnic populations in the multi-ethnic study of atherosclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423846/ https://www.ncbi.nlm.nih.gov/pubmed/25951326 http://dx.doi.org/10.1371/journal.pone.0126361 |
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