Amyloidogenic Propensity of a Natural Variant of Human Apolipoprotein A-I: Stability and Interaction with Ligands

A number of naturally occurring mutations of human apolipoprotein A-I (apoA-I) have been associated with hereditary amyloidoses. The molecular mechanisms involved in amyloid-associated pathology remain largely unknown. Here we examined the effects of the Arg173Pro point mutation in apoA-I on the str...

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Detalles Bibliográficos
Autores principales: Rosú, Silvana A., Rimoldi, Omar J., Prieto, Eduardo D., Curto, Lucrecia M., Delfino, José M., Ramella, Nahuel A., Tricerri, M. Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423886/
https://www.ncbi.nlm.nih.gov/pubmed/25950566
http://dx.doi.org/10.1371/journal.pone.0124946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423886/
https://www.ncbi.nlm.nih.gov/pubmed/25950566
http://dx.doi.org/10.1371/journal.pone.0124946

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