Mutation of Androgen Receptor N-Terminal Phosphorylation Site Tyr-267 Leads to Inhibition of Nuclear Translocation and DNA Binding

Reactivation of androgen receptor (AR) may drive recurrent prostate cancer in castrate patients. Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers. Ack1 phosphor...

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Detalles Bibliográficos
Autores principales: Karaca, Mehmet, Liu, Yuanbo, Zhang, Zhentao, De Silva, Dinuka, Parker, Joel S., Earp, H. Shelton, Whang, Young E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423977/
https://www.ncbi.nlm.nih.gov/pubmed/25950519
http://dx.doi.org/10.1371/journal.pone.0126270

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