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Structural mechanism of integrin inactivation by filamin

The activation of heterodimeric (α/β) integrin is crucial for regulating cell adhesion. Binding of talin to the cytoplasmic face of integrin activates the receptor, but how integrin is properly maintained in resting state to counterbalance its activation for regulating adhesion dynamics remains obsc...

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Detalles Bibliográficos
Autores principales:	Liu, Jianmin, Das, Mitali, Yang, Jun, Ithychanda, Sujay Subbayya, Yakubenko, Valentin P., Plow, Edward F, Qin, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424056/ https://www.ncbi.nlm.nih.gov/pubmed/25849143 http://dx.doi.org/10.1038/nsmb.2999

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