Cargando…
Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis
BACKGROUND: In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also m...
Autores principales: | Legocki, Laurie J, Meurer, William J, Frederiksen, Shirley, Lewis, Roger J, Durkalski, Valerie L, Berry, Donald A, Barsan, William G, Fetters, Michael D |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424427/ https://www.ncbi.nlm.nih.gov/pubmed/25933921 http://dx.doi.org/10.1186/s12910-015-0022-z |
Ejemplares similares
-
Attitudes and opinions regarding confirmatory adaptive clinical trials: a mixed methods analysis from the Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT) project
por: Meurer, William J., et al.
Publicado: (2016) -
The life cycles of six multi-center adaptive clinical trials focused on neurological emergencies developed for the Advancing Regulatory Science initiative of the National Institutes of Health and US Food and Drug Administration: Case studies from the Adaptive Designs Accelerating Promising Treatments Into Trials Project
por: Guetterman, Timothy C, et al.
Publicado: (2017) -
Comparison of Bayesian vs Frequentist Adaptive Trial Design in the Stroke Hyperglycemia Insulin Network Effort Trial
por: Broglio, Kristine, et al.
Publicado: (2022) -
Rapid commentary: Ethical implications for clinical trialists and patients associated with COVID-19 research
por: Delanerolle, Gayathri, et al.
Publicado: (2021) -
Conflicts of Interest, Baselga, and Clinical Trialists
por: Sartor, Oliver
Publicado: (2018)