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Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism
BACKGROUND/OBJECTIVES: Cardioprotective effects of Mediterranean-style diet have been shown. Instead of excluding foods, replacement or addition may facilitate compliance with impact on glucose metabolism of individuals at cardiometabolic risk. This study investigated the effect of changing selected...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424482/ https://www.ncbi.nlm.nih.gov/pubmed/25960776 http://dx.doi.org/10.1186/1758-5996-6-136 |
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author | de Barros, Camila Risso Cezaretto, Adriana Curti, Maíra Ladeia Rodrigues Pires, Milena Monfort Folchetti, Luciana Dias Siqueira-Catania, Antonela Ferreira, Sandra Roberta Gouvea |
author_facet | de Barros, Camila Risso Cezaretto, Adriana Curti, Maíra Ladeia Rodrigues Pires, Milena Monfort Folchetti, Luciana Dias Siqueira-Catania, Antonela Ferreira, Sandra Roberta Gouvea |
author_sort | de Barros, Camila Risso |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Cardioprotective effects of Mediterranean-style diet have been shown. Instead of excluding foods, replacement or addition may facilitate compliance with impact on glucose metabolism of individuals at cardiometabolic risk. This study investigated the effect of changing selected nutrients intake on glucose metabolism during a lifestyle intervention tailored to living conditions of prediabetic Brazilians. SUBJECTS/METHODS: 183 prediabetic adults treated under the Brazilian public health system underwent an 18-month intervention on diet and physical activity. Dietary counseling focused on reducing saturated fat replaced by unsaturated fatty acids. Data were collected at baseline and after follow-up. ANOVA and multiple linear regression were used to test association of changes in nutrients intake with changes in plasma glucose. RESULTS: Changes in fasting and 2-h plasma glucose but not in weight, HOMA-IR or C-reactive protein decreased after intervention across tertiles of MUFA changes (p-trend 0.017 and 0.024, respectively). Regression models showed that increase in MUFA intake was independently associated with reduction in fasting (β -1.475, p = 0.008) and 2-h plasma glucose (β -3.321, p = 0.007). Moreover, increase in soluble fibers intake was associated with decrease in fasting plasma glucose (β -1.579, p = 0.038). Adjustment for anthropometric measurements did not change the results but did after including change in insulin in the models. CONCLUSIONS: Increases of MUFA and soluble fibers intakes promote benefits on glucose metabolism, independently of adiposity, during a realistic lifestyle intervention in at-risk individuals. Mechanisms mediating these processes may include mainly insulin sensitivity improvement. |
format | Online Article Text |
id | pubmed-4424482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44244822015-05-09 Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism de Barros, Camila Risso Cezaretto, Adriana Curti, Maíra Ladeia Rodrigues Pires, Milena Monfort Folchetti, Luciana Dias Siqueira-Catania, Antonela Ferreira, Sandra Roberta Gouvea Diabetol Metab Syndr Research BACKGROUND/OBJECTIVES: Cardioprotective effects of Mediterranean-style diet have been shown. Instead of excluding foods, replacement or addition may facilitate compliance with impact on glucose metabolism of individuals at cardiometabolic risk. This study investigated the effect of changing selected nutrients intake on glucose metabolism during a lifestyle intervention tailored to living conditions of prediabetic Brazilians. SUBJECTS/METHODS: 183 prediabetic adults treated under the Brazilian public health system underwent an 18-month intervention on diet and physical activity. Dietary counseling focused on reducing saturated fat replaced by unsaturated fatty acids. Data were collected at baseline and after follow-up. ANOVA and multiple linear regression were used to test association of changes in nutrients intake with changes in plasma glucose. RESULTS: Changes in fasting and 2-h plasma glucose but not in weight, HOMA-IR or C-reactive protein decreased after intervention across tertiles of MUFA changes (p-trend 0.017 and 0.024, respectively). Regression models showed that increase in MUFA intake was independently associated with reduction in fasting (β -1.475, p = 0.008) and 2-h plasma glucose (β -3.321, p = 0.007). Moreover, increase in soluble fibers intake was associated with decrease in fasting plasma glucose (β -1.579, p = 0.038). Adjustment for anthropometric measurements did not change the results but did after including change in insulin in the models. CONCLUSIONS: Increases of MUFA and soluble fibers intakes promote benefits on glucose metabolism, independently of adiposity, during a realistic lifestyle intervention in at-risk individuals. Mechanisms mediating these processes may include mainly insulin sensitivity improvement. BioMed Central 2014-12-07 /pmc/articles/PMC4424482/ /pubmed/25960776 http://dx.doi.org/10.1186/1758-5996-6-136 Text en © Barros et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research de Barros, Camila Risso Cezaretto, Adriana Curti, Maíra Ladeia Rodrigues Pires, Milena Monfort Folchetti, Luciana Dias Siqueira-Catania, Antonela Ferreira, Sandra Roberta Gouvea Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title | Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title_full | Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title_fullStr | Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title_full_unstemmed | Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title_short | Realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
title_sort | realistic changes in monounsaturated fatty acids and soluble fibers are able to improve glucose metabolism |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424482/ https://www.ncbi.nlm.nih.gov/pubmed/25960776 http://dx.doi.org/10.1186/1758-5996-6-136 |
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