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ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly

BACKGROUND: ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1. METHODS: We used cell death assays, size exclusion chromatography, Co-Immunoprecipitation, shRNA lentivectors and glio...

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Detalles Bibliográficos
Autores principales:	Selmi, Tommaso, Alecci, Claudia, dell’ Aquila, Miriam, Montorsi, Lucia, Martello, Andrea, Guizzetti, Filippo, Volpi, Nicola, Parenti, Sandra, Ferrari, Sergio, Salomoni, Paolo, Grande, Alexis, Zanocco-Marani, Tommaso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424499/ https://www.ncbi.nlm.nih.gov/pubmed/25939870 http://dx.doi.org/10.1186/s12885-015-1388-5

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