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Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers

PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. Th...

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Autores principales: Zamani, Mitra, Panahi-Bazaz, Mahmoodreza, Assadi, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424712/
https://www.ncbi.nlm.nih.gov/pubmed/26005547
http://dx.doi.org/10.4103/2008-322X.156087
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author Zamani, Mitra
Panahi-Bazaz, Mahmoodreza
Assadi, Mona
author_facet Zamani, Mitra
Panahi-Bazaz, Mahmoodreza
Assadi, Mona
author_sort Zamani, Mitra
collection PubMed
description PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. The procedure was performed according to the standardized protocol for keratoconus. Preoperative medications were continued after CXL in all cases. Microbiological exams revealed Pseudomonas aeruginosa in 3 cases. Follow up continued from 1 to 10 months. RESULTS: In 6 of 8 eyes, progression of corneal melting was halted and complete epithelialization occurred. In one eye emergency keratoplasty was needed due to corneal perforation. A conjunctival flap was performed to treat severe localized corneal thinning in one of the patients a few days after CXL. Significant clinical improvement occurred in all cases of Pseudomonas aeruginosa keratitis. CONCLUSION: CXL can be considered as a promising new treatment in the management of refractory non-healing corneal ulcers, including Pseudomonas aeruginosa keratitis.
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spelling pubmed-44247122015-05-22 Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers Zamani, Mitra Panahi-Bazaz, Mahmoodreza Assadi, Mona J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. The procedure was performed according to the standardized protocol for keratoconus. Preoperative medications were continued after CXL in all cases. Microbiological exams revealed Pseudomonas aeruginosa in 3 cases. Follow up continued from 1 to 10 months. RESULTS: In 6 of 8 eyes, progression of corneal melting was halted and complete epithelialization occurred. In one eye emergency keratoplasty was needed due to corneal perforation. A conjunctival flap was performed to treat severe localized corneal thinning in one of the patients a few days after CXL. Significant clinical improvement occurred in all cases of Pseudomonas aeruginosa keratitis. CONCLUSION: CXL can be considered as a promising new treatment in the management of refractory non-healing corneal ulcers, including Pseudomonas aeruginosa keratitis. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4424712/ /pubmed/26005547 http://dx.doi.org/10.4103/2008-322X.156087 Text en Copyright: © Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zamani, Mitra
Panahi-Bazaz, Mahmoodreza
Assadi, Mona
Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title_full Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title_fullStr Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title_full_unstemmed Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title_short Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
title_sort corneal collagen cross-linking for treatment of non-healing corneal ulcers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424712/
https://www.ncbi.nlm.nih.gov/pubmed/26005547
http://dx.doi.org/10.4103/2008-322X.156087
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