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Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers
PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. Th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424712/ https://www.ncbi.nlm.nih.gov/pubmed/26005547 http://dx.doi.org/10.4103/2008-322X.156087 |
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author | Zamani, Mitra Panahi-Bazaz, Mahmoodreza Assadi, Mona |
author_facet | Zamani, Mitra Panahi-Bazaz, Mahmoodreza Assadi, Mona |
author_sort | Zamani, Mitra |
collection | PubMed |
description | PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. The procedure was performed according to the standardized protocol for keratoconus. Preoperative medications were continued after CXL in all cases. Microbiological exams revealed Pseudomonas aeruginosa in 3 cases. Follow up continued from 1 to 10 months. RESULTS: In 6 of 8 eyes, progression of corneal melting was halted and complete epithelialization occurred. In one eye emergency keratoplasty was needed due to corneal perforation. A conjunctival flap was performed to treat severe localized corneal thinning in one of the patients a few days after CXL. Significant clinical improvement occurred in all cases of Pseudomonas aeruginosa keratitis. CONCLUSION: CXL can be considered as a promising new treatment in the management of refractory non-healing corneal ulcers, including Pseudomonas aeruginosa keratitis. |
format | Online Article Text |
id | pubmed-4424712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44247122015-05-22 Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers Zamani, Mitra Panahi-Bazaz, Mahmoodreza Assadi, Mona J Ophthalmic Vis Res Original Article PURPOSE: To evaluate the efficacy of corneal collagen cross-linking (CXL) for treatment of corneal ulcers not responding to antimicrobial therapy. METHODS: Eight patients with corneal ulcers associated with corneal melting, not responding to conventional antibiotic therapy, were treated with CXL. The procedure was performed according to the standardized protocol for keratoconus. Preoperative medications were continued after CXL in all cases. Microbiological exams revealed Pseudomonas aeruginosa in 3 cases. Follow up continued from 1 to 10 months. RESULTS: In 6 of 8 eyes, progression of corneal melting was halted and complete epithelialization occurred. In one eye emergency keratoplasty was needed due to corneal perforation. A conjunctival flap was performed to treat severe localized corneal thinning in one of the patients a few days after CXL. Significant clinical improvement occurred in all cases of Pseudomonas aeruginosa keratitis. CONCLUSION: CXL can be considered as a promising new treatment in the management of refractory non-healing corneal ulcers, including Pseudomonas aeruginosa keratitis. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4424712/ /pubmed/26005547 http://dx.doi.org/10.4103/2008-322X.156087 Text en Copyright: © Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Zamani, Mitra Panahi-Bazaz, Mahmoodreza Assadi, Mona Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title | Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title_full | Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title_fullStr | Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title_full_unstemmed | Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title_short | Corneal Collagen Cross-linking for Treatment of Non-healing Corneal Ulcers |
title_sort | corneal collagen cross-linking for treatment of non-healing corneal ulcers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424712/ https://www.ncbi.nlm.nih.gov/pubmed/26005547 http://dx.doi.org/10.4103/2008-322X.156087 |
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