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Peripheral nerve regeneration with conduits: use of vein tubes

Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental n...

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Autores principales: Sabongi, Rodrigo Guerra, Fernandes, Marcela, dos Santos, João Baptista Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424734/
https://www.ncbi.nlm.nih.gov/pubmed/26170802
http://dx.doi.org/10.4103/1673-5374.155428
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author Sabongi, Rodrigo Guerra
Fernandes, Marcela
dos Santos, João Baptista Gomes
author_facet Sabongi, Rodrigo Guerra
Fernandes, Marcela
dos Santos, João Baptista Gomes
author_sort Sabongi, Rodrigo Guerra
collection PubMed
description Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit.
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spelling pubmed-44247342015-07-13 Peripheral nerve regeneration with conduits: use of vein tubes Sabongi, Rodrigo Guerra Fernandes, Marcela dos Santos, João Baptista Gomes Neural Regen Res Invited Review Treatment of peripheral nerve injuries remains a challenge to modern medicine due to the complexity of the neurobiological nerve regenerating process. There is a greater challenge when the transected nerve ends are not amenable to primary end-to-end tensionless neurorraphy. When facing a segmental nerve defect, great effort has been made to develop an alternative to the autologous nerve graft in order to circumvent morbidity at donor site, such as neuroma formation, scarring and permanent loss of function. Tubolization techniques have been developed to bridge nerve gaps and have been extensively studied in numerous experimental and clinical trials. The use of a conduit intends to act as a vehicle for moderation and modulation of the cellular and molecular ambience for nerve regeneration. Among several conduits, vein tubes were validated for clinical application with improving outcomes over the years. This article aims to address the investigation and treatment of segmental nerve injury and draw the current panorama on the use of vein tubes as an autogenous nerve conduit. Medknow Publications & Media Pvt Ltd 2015-04 /pmc/articles/PMC4424734/ /pubmed/26170802 http://dx.doi.org/10.4103/1673-5374.155428 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Sabongi, Rodrigo Guerra
Fernandes, Marcela
dos Santos, João Baptista Gomes
Peripheral nerve regeneration with conduits: use of vein tubes
title Peripheral nerve regeneration with conduits: use of vein tubes
title_full Peripheral nerve regeneration with conduits: use of vein tubes
title_fullStr Peripheral nerve regeneration with conduits: use of vein tubes
title_full_unstemmed Peripheral nerve regeneration with conduits: use of vein tubes
title_short Peripheral nerve regeneration with conduits: use of vein tubes
title_sort peripheral nerve regeneration with conduits: use of vein tubes
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424734/
https://www.ncbi.nlm.nih.gov/pubmed/26170802
http://dx.doi.org/10.4103/1673-5374.155428
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