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Identification of essential residues for binding and activation in the human 5-HT(7(a)) serotonin receptor by molecular modeling and site-directed mutagenesis
The human 5-HT(7) receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding and G protein activation by the human 5-HT(7(a)) receptor. The role of severa...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424842/ https://www.ncbi.nlm.nih.gov/pubmed/26005408 http://dx.doi.org/10.3389/fnbeh.2015.00092 |