Cargando…

Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology

Nano SiO(2) and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO(2), 1.0 wt % MgO, 0.5 wt % SiO(2) + 1.0 wt % MgO were fabricated via selective laser sinte...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Chengde, Wei, Pingpin, Feng, Pei, Xiao, Tao, Shuai, Cijun, Peng, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424989/
https://www.ncbi.nlm.nih.gov/pubmed/25815597
http://dx.doi.org/10.3390/ijms16046818
Descripción
Sumario:Nano SiO(2) and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO(2), 1.0 wt % MgO, 0.5 wt % SiO(2) + 1.0 wt % MgO were fabricated via selective laser sintering respectively and undoped β-TCP scaffold was also prepared as control. The phase composition and mechanical strength of the scaffolds were evaluated. X-ray diffraction analysis indicated that the phase transformation from β-TCP to α-TCP was inhibited after the addition of MgO. The compressive strength of scaffold was improved from 3.12 ± 0.36 MPa (β-TCP) to 5.74 ± 0.62 MPa (β-TCP/SiO(2)), 9.02 ± 0.55 MPa (β-TCP/MgO) and 10.43 ± 0.28 MPa (β-TCP/SiO(2)/MgO), respectively. The weight loss and apatite-forming ability of the scaffolds were evaluated by soaking them in simulated body fluid. The results demonstrated that both SiO(2) and MgO dopings slowed down the degradation rate and improved the bioactivity of β-TCP scaffolds. In vitro cell culture studies indicated that SiO(2) and MgO dopings facilitated cell attachment and proliferation. Combined addition of SiO(2) and MgO were found optimal in enhancing both the mechanical and biological properties of β-TCP scaffold.