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Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology
Nano SiO(2) and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO(2), 1.0 wt % MgO, 0.5 wt % SiO(2) + 1.0 wt % MgO were fabricated via selective laser sinte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424989/ https://www.ncbi.nlm.nih.gov/pubmed/25815597 http://dx.doi.org/10.3390/ijms16046818 |
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author | Gao, Chengde Wei, Pingpin Feng, Pei Xiao, Tao Shuai, Cijun Peng, Shuping |
author_facet | Gao, Chengde Wei, Pingpin Feng, Pei Xiao, Tao Shuai, Cijun Peng, Shuping |
author_sort | Gao, Chengde |
collection | PubMed |
description | Nano SiO(2) and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO(2), 1.0 wt % MgO, 0.5 wt % SiO(2) + 1.0 wt % MgO were fabricated via selective laser sintering respectively and undoped β-TCP scaffold was also prepared as control. The phase composition and mechanical strength of the scaffolds were evaluated. X-ray diffraction analysis indicated that the phase transformation from β-TCP to α-TCP was inhibited after the addition of MgO. The compressive strength of scaffold was improved from 3.12 ± 0.36 MPa (β-TCP) to 5.74 ± 0.62 MPa (β-TCP/SiO(2)), 9.02 ± 0.55 MPa (β-TCP/MgO) and 10.43 ± 0.28 MPa (β-TCP/SiO(2)/MgO), respectively. The weight loss and apatite-forming ability of the scaffolds were evaluated by soaking them in simulated body fluid. The results demonstrated that both SiO(2) and MgO dopings slowed down the degradation rate and improved the bioactivity of β-TCP scaffolds. In vitro cell culture studies indicated that SiO(2) and MgO dopings facilitated cell attachment and proliferation. Combined addition of SiO(2) and MgO were found optimal in enhancing both the mechanical and biological properties of β-TCP scaffold. |
format | Online Article Text |
id | pubmed-4424989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44249892015-05-20 Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology Gao, Chengde Wei, Pingpin Feng, Pei Xiao, Tao Shuai, Cijun Peng, Shuping Int J Mol Sci Article Nano SiO(2) and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO(2), 1.0 wt % MgO, 0.5 wt % SiO(2) + 1.0 wt % MgO were fabricated via selective laser sintering respectively and undoped β-TCP scaffold was also prepared as control. The phase composition and mechanical strength of the scaffolds were evaluated. X-ray diffraction analysis indicated that the phase transformation from β-TCP to α-TCP was inhibited after the addition of MgO. The compressive strength of scaffold was improved from 3.12 ± 0.36 MPa (β-TCP) to 5.74 ± 0.62 MPa (β-TCP/SiO(2)), 9.02 ± 0.55 MPa (β-TCP/MgO) and 10.43 ± 0.28 MPa (β-TCP/SiO(2)/MgO), respectively. The weight loss and apatite-forming ability of the scaffolds were evaluated by soaking them in simulated body fluid. The results demonstrated that both SiO(2) and MgO dopings slowed down the degradation rate and improved the bioactivity of β-TCP scaffolds. In vitro cell culture studies indicated that SiO(2) and MgO dopings facilitated cell attachment and proliferation. Combined addition of SiO(2) and MgO were found optimal in enhancing both the mechanical and biological properties of β-TCP scaffold. MDPI 2015-03-25 /pmc/articles/PMC4424989/ /pubmed/25815597 http://dx.doi.org/10.3390/ijms16046818 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gao, Chengde Wei, Pingpin Feng, Pei Xiao, Tao Shuai, Cijun Peng, Shuping Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title | Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title_full | Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title_fullStr | Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title_full_unstemmed | Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title_short | Nano SiO(2) and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology |
title_sort | nano sio(2) and mgo improve the properties of porous β-tcp scaffolds via advanced manufacturing technology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424989/ https://www.ncbi.nlm.nih.gov/pubmed/25815597 http://dx.doi.org/10.3390/ijms16046818 |
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