Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering

Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth fact...

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Autores principales: Lee, Sujin, Lee, Dong-Sung, Choi, Ilsan, Pham, Le B. Hang, Jang, Jun-Hyeog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425042/
https://www.ncbi.nlm.nih.gov/pubmed/25853265
http://dx.doi.org/10.3390/ijms16047672
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author Lee, Sujin
Lee, Dong-Sung
Choi, Ilsan
Pham, Le B. Hang
Jang, Jun-Hyeog
author_facet Lee, Sujin
Lee, Dong-Sung
Choi, Ilsan
Pham, Le B. Hang
Jang, Jun-Hyeog
author_sort Lee, Sujin
collection PubMed
description Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05).
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spelling pubmed-44250422015-05-20 Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering Lee, Sujin Lee, Dong-Sung Choi, Ilsan Pham, Le B. Hang Jang, Jun-Hyeog Int J Mol Sci Article Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05). MDPI 2015-04-07 /pmc/articles/PMC4425042/ /pubmed/25853265 http://dx.doi.org/10.3390/ijms16047672 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Sujin
Lee, Dong-Sung
Choi, Ilsan
Pham, Le B. Hang
Jang, Jun-Hyeog
Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title_full Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title_fullStr Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title_full_unstemmed Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title_short Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
title_sort design of an osteoinductive extracellular fibronectin matrix protein for bone tissue engineering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425042/
https://www.ncbi.nlm.nih.gov/pubmed/25853265
http://dx.doi.org/10.3390/ijms16047672
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