Cargando…
Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Va...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425057/ https://www.ncbi.nlm.nih.gov/pubmed/25860946 http://dx.doi.org/10.3390/ijms16047900 |
_version_ | 1782370432413859840 |
---|---|
author | Moghaddam, Arash Child, Christopher Bruckner, Thomas Gerner, Hans Jürgen Daniel, Volker Biglari, Bahram |
author_facet | Moghaddam, Arash Child, Christopher Bruckner, Thomas Gerner, Hans Jürgen Daniel, Volker Biglari, Bahram |
author_sort | Moghaddam, Arash |
collection | PubMed |
description | Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques. |
format | Online Article Text |
id | pubmed-4425057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44250572015-05-20 Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury Moghaddam, Arash Child, Christopher Bruckner, Thomas Gerner, Hans Jürgen Daniel, Volker Biglari, Bahram Int J Mol Sci Article Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques. MDPI 2015-04-09 /pmc/articles/PMC4425057/ /pubmed/25860946 http://dx.doi.org/10.3390/ijms16047900 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Moghaddam, Arash Child, Christopher Bruckner, Thomas Gerner, Hans Jürgen Daniel, Volker Biglari, Bahram Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title | Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title_full | Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title_fullStr | Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title_full_unstemmed | Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title_short | Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury |
title_sort | posttraumatic inflammation as a key to neuroregeneration after traumatic spinal cord injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425057/ https://www.ncbi.nlm.nih.gov/pubmed/25860946 http://dx.doi.org/10.3390/ijms16047900 |
work_keys_str_mv | AT moghaddamarash posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury AT childchristopher posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury AT brucknerthomas posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury AT gernerhansjurgen posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury AT danielvolker posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury AT biglaribahram posttraumaticinflammationasakeytoneuroregenerationaftertraumaticspinalcordinjury |