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Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury

Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Va...

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Autores principales: Moghaddam, Arash, Child, Christopher, Bruckner, Thomas, Gerner, Hans Jürgen, Daniel, Volker, Biglari, Bahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425057/
https://www.ncbi.nlm.nih.gov/pubmed/25860946
http://dx.doi.org/10.3390/ijms16047900
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author Moghaddam, Arash
Child, Christopher
Bruckner, Thomas
Gerner, Hans Jürgen
Daniel, Volker
Biglari, Bahram
author_facet Moghaddam, Arash
Child, Christopher
Bruckner, Thomas
Gerner, Hans Jürgen
Daniel, Volker
Biglari, Bahram
author_sort Moghaddam, Arash
collection PubMed
description Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques.
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spelling pubmed-44250572015-05-20 Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury Moghaddam, Arash Child, Christopher Bruckner, Thomas Gerner, Hans Jürgen Daniel, Volker Biglari, Bahram Int J Mol Sci Article Pro- and anti-inflammatory cytokines might have a large impact on the secondary phase and on the neurological outcome of patients with acute spinal cord injury (SCI). We measured the serum levels of different cytokines (Interferon-γ, Tumor Necrosis Factor-α, Interleukin-1β, IL-6, IL-8, IL-10, and Vascular Endothelial Growth Factor) over a 12-week period in 40 acute traumatic SCI patients: at admission on average one hour after initial trauma; at four, nine, 12, and 24 h; Three, and seven days after admission; and two, four, eight, and twelve weeks after admission. This was done using a Luminex Performance Human High Sensitivity Cytokine Panel. SCI was classified using the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at time of admission and after 12 weeks. TNFα, IL-1β, IL-6, IL-8, and IL-10 concentrations were significantly higher in patients without neurological remission and in patients with an initial AIS A (p < 0.05). This study shows significant differences in cytokine concentrations shown in traumatic SCI patients with different neurological impairments and within a 12-week period. IL-8 and IL-10 are potential peripheral markers for neurological remission and rehabilitation after traumatic SCI. Furthermore our cytokine expression pattern of the acute, subacute, and intermediate phase of SCI establishes a possible basis for future studies to develop standardized monitoring, prognostic, and tracking techniques. MDPI 2015-04-09 /pmc/articles/PMC4425057/ /pubmed/25860946 http://dx.doi.org/10.3390/ijms16047900 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moghaddam, Arash
Child, Christopher
Bruckner, Thomas
Gerner, Hans Jürgen
Daniel, Volker
Biglari, Bahram
Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title_full Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title_fullStr Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title_full_unstemmed Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title_short Posttraumatic Inflammation as a Key to Neuroregeneration after Traumatic Spinal Cord Injury
title_sort posttraumatic inflammation as a key to neuroregeneration after traumatic spinal cord injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425057/
https://www.ncbi.nlm.nih.gov/pubmed/25860946
http://dx.doi.org/10.3390/ijms16047900
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