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Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment

With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the biological activity of the resinous exudate of aerial parts from Psoralea glandulosa, and its active components (bakuchiol (1), 3-hydroxy-bakuch...

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Autores principales: Madrid, Alejandro, Cardile, Venera, González, César, Montenegro, Ivan, Villena, Joan, Caggia, Silvia, Graziano, Adriana, Russo, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425060/
https://www.ncbi.nlm.nih.gov/pubmed/25860949
http://dx.doi.org/10.3390/ijms16047944
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author Madrid, Alejandro
Cardile, Venera
González, César
Montenegro, Ivan
Villena, Joan
Caggia, Silvia
Graziano, Adriana
Russo, Alessandra
author_facet Madrid, Alejandro
Cardile, Venera
González, César
Montenegro, Ivan
Villena, Joan
Caggia, Silvia
Graziano, Adriana
Russo, Alessandra
author_sort Madrid, Alejandro
collection PubMed
description With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the biological activity of the resinous exudate of aerial parts from Psoralea glandulosa, and its active components (bakuchiol (1), 3-hydroxy-bakuchiol (2) and 12-hydroxy-iso-bakuchiol (3)) against melanoma cells (A2058). In addition, the effect in cancer cells of bakuchiol acetate (4), a semi-synthetic derivative of bakuchiol, was examined. The results obtained show that the resinous exudate inhibited the growth of cancer cells with IC(50) value of 10.5 μg/mL after 48 h of treatment, while, for pure compounds, the most active was the semi-synthetic compound 4. Our data also demonstrate that resin is able to induce apoptotic cell death, which could be related to an overall action of the meroterpenes present. In addition, our data seem to indicate that the apoptosis correlated to the tested products appears, at least in part, to be associated with an increase of reactive oxygen species (ROS) production. In summary, our study provides the first evidence that P. glandulosa may be considered a source of useful molecules in the development of analogues with more potent efficacy against melanoma cells.
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spelling pubmed-44250602015-05-20 Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment Madrid, Alejandro Cardile, Venera González, César Montenegro, Ivan Villena, Joan Caggia, Silvia Graziano, Adriana Russo, Alessandra Int J Mol Sci Article With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the biological activity of the resinous exudate of aerial parts from Psoralea glandulosa, and its active components (bakuchiol (1), 3-hydroxy-bakuchiol (2) and 12-hydroxy-iso-bakuchiol (3)) against melanoma cells (A2058). In addition, the effect in cancer cells of bakuchiol acetate (4), a semi-synthetic derivative of bakuchiol, was examined. The results obtained show that the resinous exudate inhibited the growth of cancer cells with IC(50) value of 10.5 μg/mL after 48 h of treatment, while, for pure compounds, the most active was the semi-synthetic compound 4. Our data also demonstrate that resin is able to induce apoptotic cell death, which could be related to an overall action of the meroterpenes present. In addition, our data seem to indicate that the apoptosis correlated to the tested products appears, at least in part, to be associated with an increase of reactive oxygen species (ROS) production. In summary, our study provides the first evidence that P. glandulosa may be considered a source of useful molecules in the development of analogues with more potent efficacy against melanoma cells. MDPI 2015-04-09 /pmc/articles/PMC4425060/ /pubmed/25860949 http://dx.doi.org/10.3390/ijms16047944 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madrid, Alejandro
Cardile, Venera
González, César
Montenegro, Ivan
Villena, Joan
Caggia, Silvia
Graziano, Adriana
Russo, Alessandra
Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title_full Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title_fullStr Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title_full_unstemmed Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title_short Psoralea glandulosa as a Potential Source of Anticancer Agents for Melanoma Treatment
title_sort psoralea glandulosa as a potential source of anticancer agents for melanoma treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425060/
https://www.ncbi.nlm.nih.gov/pubmed/25860949
http://dx.doi.org/10.3390/ijms16047944
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