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VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy

The VEGFR-1 is suggested to promote tumor progression. In the current study we analyzed prevalence and prognostic impact of the VEGFR-1 by immunohistochemistry on a tissue microarray containing more than 3000 prostate cancer specimens. Results were compared to tumor phenotype, ETS-related gene (ERG)...

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Autores principales: Tsourlakis, Maria Christina, Khosrawi, Puya, Weigand, Philipp, Kluth, Martina, Hube-Magg, Claudia, Minner, Sarah, Koop, Christina, Graefen, Markus, Heinzer, Hans, Wittmer, Corinna, Sauter, Guido, Krech, Till, Wilczak, Waldemar, Huland, Hartwig, Simon, Ronald, Schlomm, Thorsten, Steurer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425098/
https://www.ncbi.nlm.nih.gov/pubmed/25894226
http://dx.doi.org/10.3390/ijms16048591
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author Tsourlakis, Maria Christina
Khosrawi, Puya
Weigand, Philipp
Kluth, Martina
Hube-Magg, Claudia
Minner, Sarah
Koop, Christina
Graefen, Markus
Heinzer, Hans
Wittmer, Corinna
Sauter, Guido
Krech, Till
Wilczak, Waldemar
Huland, Hartwig
Simon, Ronald
Schlomm, Thorsten
Steurer, Stefan
author_facet Tsourlakis, Maria Christina
Khosrawi, Puya
Weigand, Philipp
Kluth, Martina
Hube-Magg, Claudia
Minner, Sarah
Koop, Christina
Graefen, Markus
Heinzer, Hans
Wittmer, Corinna
Sauter, Guido
Krech, Till
Wilczak, Waldemar
Huland, Hartwig
Simon, Ronald
Schlomm, Thorsten
Steurer, Stefan
author_sort Tsourlakis, Maria Christina
collection PubMed
description The VEGFR-1 is suggested to promote tumor progression. In the current study we analyzed prevalence and prognostic impact of the VEGFR-1 by immunohistochemistry on a tissue microarray containing more than 3000 prostate cancer specimens. Results were compared to tumor phenotype, ETS-related gene (ERG) status, and biochemical recurrence. Membranous VEGFR-1 expression was detectable in 32.6% of 2669 interpretable cancers and considered strong in 1.7%, moderate in 6.7% and weak in 24.2% of cases. Strong VEGFR-1 expression was associated with TMPRSS2:ERG fusion status as determined by fluorescence in situ hybridization (FISH) and immunohistochemistry (p < 0.0001 each). Elevated VEGFR-1 expression was linked to high Gleason grade and advanced pT stage in TMPRSS2:ERG negative cancers (p = 0.0008 and p = 0.001), while these associations were absent in TMPRSS2:ERG positive cancers. VEGFR-1 expression was also linked to phosphatase and tensin homolog (PTEN) deletions. A comparison with prostate specific antigen (PSA) recurrence revealed that the 1.7% of prostate cancers with the highest VEGFR-1 levels had a strikingly unfavorable prognosis. This could be seen in all cancers, in the subsets of TMPRSS2:ERG positive or negative, PTEN deleted or undeleted carcinomas (p < 0.0001 each). High level VEGFR-1 expression is infrequent in prostate cancer, but identifies a subgroup of aggressive cancers, which may be candidates for anti-VEGFR-1 targeted therapy.
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spelling pubmed-44250982015-05-20 VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy Tsourlakis, Maria Christina Khosrawi, Puya Weigand, Philipp Kluth, Martina Hube-Magg, Claudia Minner, Sarah Koop, Christina Graefen, Markus Heinzer, Hans Wittmer, Corinna Sauter, Guido Krech, Till Wilczak, Waldemar Huland, Hartwig Simon, Ronald Schlomm, Thorsten Steurer, Stefan Int J Mol Sci Article The VEGFR-1 is suggested to promote tumor progression. In the current study we analyzed prevalence and prognostic impact of the VEGFR-1 by immunohistochemistry on a tissue microarray containing more than 3000 prostate cancer specimens. Results were compared to tumor phenotype, ETS-related gene (ERG) status, and biochemical recurrence. Membranous VEGFR-1 expression was detectable in 32.6% of 2669 interpretable cancers and considered strong in 1.7%, moderate in 6.7% and weak in 24.2% of cases. Strong VEGFR-1 expression was associated with TMPRSS2:ERG fusion status as determined by fluorescence in situ hybridization (FISH) and immunohistochemistry (p < 0.0001 each). Elevated VEGFR-1 expression was linked to high Gleason grade and advanced pT stage in TMPRSS2:ERG negative cancers (p = 0.0008 and p = 0.001), while these associations were absent in TMPRSS2:ERG positive cancers. VEGFR-1 expression was also linked to phosphatase and tensin homolog (PTEN) deletions. A comparison with prostate specific antigen (PSA) recurrence revealed that the 1.7% of prostate cancers with the highest VEGFR-1 levels had a strikingly unfavorable prognosis. This could be seen in all cancers, in the subsets of TMPRSS2:ERG positive or negative, PTEN deleted or undeleted carcinomas (p < 0.0001 each). High level VEGFR-1 expression is infrequent in prostate cancer, but identifies a subgroup of aggressive cancers, which may be candidates for anti-VEGFR-1 targeted therapy. MDPI 2015-04-16 /pmc/articles/PMC4425098/ /pubmed/25894226 http://dx.doi.org/10.3390/ijms16048591 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsourlakis, Maria Christina
Khosrawi, Puya
Weigand, Philipp
Kluth, Martina
Hube-Magg, Claudia
Minner, Sarah
Koop, Christina
Graefen, Markus
Heinzer, Hans
Wittmer, Corinna
Sauter, Guido
Krech, Till
Wilczak, Waldemar
Huland, Hartwig
Simon, Ronald
Schlomm, Thorsten
Steurer, Stefan
VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title_full VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title_fullStr VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title_full_unstemmed VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title_short VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
title_sort vegfr-1 overexpression identifies a small subgroup of aggressive prostate cancers in patients treated by prostatectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425098/
https://www.ncbi.nlm.nih.gov/pubmed/25894226
http://dx.doi.org/10.3390/ijms16048591
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