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Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics

Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can...

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Detalles Bibliográficos
Autores principales: Majem, Blanca, Rigau, Marina, Reventós, Jaume, Wong, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425103/
https://www.ncbi.nlm.nih.gov/pubmed/25898412
http://dx.doi.org/10.3390/ijms16048676
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author Majem, Blanca
Rigau, Marina
Reventós, Jaume
Wong, David T.
author_facet Majem, Blanca
Rigau, Marina
Reventós, Jaume
Wong, David T.
author_sort Majem, Blanca
collection PubMed
description Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information.
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spelling pubmed-44251032015-05-20 Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics Majem, Blanca Rigau, Marina Reventós, Jaume Wong, David T. Int J Mol Sci Review Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information. MDPI 2015-04-17 /pmc/articles/PMC4425103/ /pubmed/25898412 http://dx.doi.org/10.3390/ijms16048676 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Majem, Blanca
Rigau, Marina
Reventós, Jaume
Wong, David T.
Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title_full Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title_fullStr Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title_full_unstemmed Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title_short Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
title_sort non-coding rnas in saliva: emerging biomarkers for molecular diagnostics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425103/
https://www.ncbi.nlm.nih.gov/pubmed/25898412
http://dx.doi.org/10.3390/ijms16048676
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