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Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics
Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425103/ https://www.ncbi.nlm.nih.gov/pubmed/25898412 http://dx.doi.org/10.3390/ijms16048676 |
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author | Majem, Blanca Rigau, Marina Reventós, Jaume Wong, David T. |
author_facet | Majem, Blanca Rigau, Marina Reventós, Jaume Wong, David T. |
author_sort | Majem, Blanca |
collection | PubMed |
description | Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information. |
format | Online Article Text |
id | pubmed-4425103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44251032015-05-20 Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics Majem, Blanca Rigau, Marina Reventós, Jaume Wong, David T. Int J Mol Sci Review Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva. Many studies have reported that saliva body fluid can be useful for discriminating several oral diseases, but also systemic diseases including cancer. Most of these studies revealed messenger RNA (mRNA) and proteomic biomarker signatures rather than specific non-coding RNA (ncRNA) profiles. NcRNAs are emerging as new regulators of diverse biological functions, playing an important role in oncogenesis and tumor progression. Indeed, the small size of these molecules makes them very stable in different body fluids and not as susceptible as mRNAs to degradation by ribonucleases (RNases). Therefore, the development of a non-invasive salivary test, based on ncRNAs profiles, could have a significant applicability to clinical practice, not only by reducing the cost of the health system, but also by benefitting the patient. Here, we summarize the current status and clinical implications of the ncRNAs present in human saliva as a source of biological information. MDPI 2015-04-17 /pmc/articles/PMC4425103/ /pubmed/25898412 http://dx.doi.org/10.3390/ijms16048676 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Majem, Blanca Rigau, Marina Reventós, Jaume Wong, David T. Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title | Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title_full | Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title_fullStr | Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title_full_unstemmed | Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title_short | Non-Coding RNAs in Saliva: Emerging Biomarkers for Molecular Diagnostics |
title_sort | non-coding rnas in saliva: emerging biomarkers for molecular diagnostics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425103/ https://www.ncbi.nlm.nih.gov/pubmed/25898412 http://dx.doi.org/10.3390/ijms16048676 |
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