Cargando…

Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease

Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiying, Lv, Shishi, Chen, Guo, Gao, Chenlin, He, Jianhua, Zhong, Haihua, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425156/
https://www.ncbi.nlm.nih.gov/pubmed/25854833
http://dx.doi.org/10.3390/nu7042485
_version_ 1782370453122187264
author Wang, Jiying
Lv, Shishi
Chen, Guo
Gao, Chenlin
He, Jianhua
Zhong, Haihua
Xu, Yong
author_facet Wang, Jiying
Lv, Shishi
Chen, Guo
Gao, Chenlin
He, Jianhua
Zhong, Haihua
Xu, Yong
author_sort Wang, Jiying
collection PubMed
description Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: −0.99, 95% CI: −1.31, −0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.
format Online
Article
Text
id pubmed-4425156
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44251562015-05-11 Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease Wang, Jiying Lv, Shishi Chen, Guo Gao, Chenlin He, Jianhua Zhong, Haihua Xu, Yong Nutrients Review Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: −0.99, 95% CI: −1.31, −0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD. MDPI 2015-04-03 /pmc/articles/PMC4425156/ /pubmed/25854833 http://dx.doi.org/10.3390/nu7042485 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Jiying
Lv, Shishi
Chen, Guo
Gao, Chenlin
He, Jianhua
Zhong, Haihua
Xu, Yong
Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title_full Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title_fullStr Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title_full_unstemmed Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title_short Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
title_sort meta-analysis of the association between vitamin d and autoimmune thyroid disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425156/
https://www.ncbi.nlm.nih.gov/pubmed/25854833
http://dx.doi.org/10.3390/nu7042485
work_keys_str_mv AT wangjiying metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT lvshishi metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT chenguo metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT gaochenlin metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT hejianhua metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT zhonghaihua metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease
AT xuyong metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease