Cargando…
Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease
Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. Th...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425156/ https://www.ncbi.nlm.nih.gov/pubmed/25854833 http://dx.doi.org/10.3390/nu7042485 |
_version_ | 1782370453122187264 |
---|---|
author | Wang, Jiying Lv, Shishi Chen, Guo Gao, Chenlin He, Jianhua Zhong, Haihua Xu, Yong |
author_facet | Wang, Jiying Lv, Shishi Chen, Guo Gao, Chenlin He, Jianhua Zhong, Haihua Xu, Yong |
author_sort | Wang, Jiying |
collection | PubMed |
description | Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: −0.99, 95% CI: −1.31, −0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD. |
format | Online Article Text |
id | pubmed-4425156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44251562015-05-11 Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease Wang, Jiying Lv, Shishi Chen, Guo Gao, Chenlin He, Jianhua Zhong, Haihua Xu, Yong Nutrients Review Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: −0.99, 95% CI: −1.31, −0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD. MDPI 2015-04-03 /pmc/articles/PMC4425156/ /pubmed/25854833 http://dx.doi.org/10.3390/nu7042485 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Jiying Lv, Shishi Chen, Guo Gao, Chenlin He, Jianhua Zhong, Haihua Xu, Yong Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title | Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title_full | Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title_fullStr | Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title_full_unstemmed | Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title_short | Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease |
title_sort | meta-analysis of the association between vitamin d and autoimmune thyroid disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425156/ https://www.ncbi.nlm.nih.gov/pubmed/25854833 http://dx.doi.org/10.3390/nu7042485 |
work_keys_str_mv | AT wangjiying metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT lvshishi metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT chenguo metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT gaochenlin metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT hejianhua metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT zhonghaihua metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease AT xuyong metaanalysisoftheassociationbetweenvitamindandautoimmunethyroiddisease |