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Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice

The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32...

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Autores principales: Seo, Eunhui, Kim, Sunmi, Lee, Sang Jun, Oh, Byung-Chul, Jun, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425188/
https://www.ncbi.nlm.nih.gov/pubmed/25912041
http://dx.doi.org/10.3390/nu7043038
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author Seo, Eunhui
Kim, Sunmi
Lee, Sang Jun
Oh, Byung-Chul
Jun, Hee-Sook
author_facet Seo, Eunhui
Kim, Sunmi
Lee, Sang Jun
Oh, Byung-Chul
Jun, Hee-Sook
author_sort Seo, Eunhui
collection PubMed
description The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resistance scores (HOMA-IR) (p = 0.012), suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice (p = 0.007). Protein levels of tyrosine phosphorylated insulin receptor substrate (IRS)-1 (p = 0.047), and protein kinase B (AKT) (p = 0.037), were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 (FOXO1) (p = 0.036) and peroxisome proliferator-activated receptor gamma (PPARγ) (p = 0.032), which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice.
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spelling pubmed-44251882015-05-11 Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice Seo, Eunhui Kim, Sunmi Lee, Sang Jun Oh, Byung-Chul Jun, Hee-Sook Nutrients Article The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resistance scores (HOMA-IR) (p = 0.012), suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice (p = 0.007). Protein levels of tyrosine phosphorylated insulin receptor substrate (IRS)-1 (p = 0.047), and protein kinase B (AKT) (p = 0.037), were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 (FOXO1) (p = 0.036) and peroxisome proliferator-activated receptor gamma (PPARγ) (p = 0.032), which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice. MDPI 2015-04-22 /pmc/articles/PMC4425188/ /pubmed/25912041 http://dx.doi.org/10.3390/nu7043038 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seo, Eunhui
Kim, Sunmi
Lee, Sang Jun
Oh, Byung-Chul
Jun, Hee-Sook
Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title_full Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title_fullStr Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title_full_unstemmed Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title_short Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in Mice
title_sort ginseng berry extract supplementation improves age-related decline of insulin signaling in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425188/
https://www.ncbi.nlm.nih.gov/pubmed/25912041
http://dx.doi.org/10.3390/nu7043038
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