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Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity

Copy number variants (CNVs) have been implicated as an important genetic marker of obesity, and gene-environment interaction has been found to modulate risk of obesity. To evaluate the associations between CNVs and childhood obesity, as well as the interactions between CNVs and dietary behaviors, we...

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Autores principales: Zhang, Dandan, Li, Zhenli, Wang, Hao, Yang, Min, Liang, Li, Fu, Junfen, Wang, Chunling, Ling, Jie, Zhang, Yan, Zhang, Shuai, Xu, Yuyang, Zhu, Yimin, Lai, Maode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425189/
https://www.ncbi.nlm.nih.gov/pubmed/25912042
http://dx.doi.org/10.3390/nu7043054
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author Zhang, Dandan
Li, Zhenli
Wang, Hao
Yang, Min
Liang, Li
Fu, Junfen
Wang, Chunling
Ling, Jie
Zhang, Yan
Zhang, Shuai
Xu, Yuyang
Zhu, Yimin
Lai, Maode
author_facet Zhang, Dandan
Li, Zhenli
Wang, Hao
Yang, Min
Liang, Li
Fu, Junfen
Wang, Chunling
Ling, Jie
Zhang, Yan
Zhang, Shuai
Xu, Yuyang
Zhu, Yimin
Lai, Maode
author_sort Zhang, Dandan
collection PubMed
description Copy number variants (CNVs) have been implicated as an important genetic marker of obesity, and gene-environment interaction has been found to modulate risk of obesity. To evaluate the associations between CNVs and childhood obesity, as well as the interactions between CNVs and dietary behaviors, we recruited 534 obese children and 508 controls from six cities in China and six candidate CNVs were screened through published genome-wide studies (GWAS) on childhood obesity. We found three loci (10q11.22, 4q25 and 11q11) to be significantly associated with obesity after false discovery rate (FDR) correction (all the p ≤ 0.05). Cumulative effect of the three positive loci was measured by the genetic risk score (GRS), showing a significant relationship with the risk of obesity (P(trend) < 0.001). The OR of obesity increased to 21.38 (95% CI = 21.19–21.55) among the 10q11.22 deletion carriers who had meat-based diets, indicating prominent multiplicative interaction (MI) between deletions of 10q11.22 and preference for a meat-based diet. Simultaneous deletions of 5q13.2 and duplications of 6q14.1 had significant MI with a preference for salty foods. Our results suggested that CNVs may contribute to the genetic susceptibility of childhood obesity, and the CNV-diet interactions modulate the risk of obesity.
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spelling pubmed-44251892015-05-11 Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity Zhang, Dandan Li, Zhenli Wang, Hao Yang, Min Liang, Li Fu, Junfen Wang, Chunling Ling, Jie Zhang, Yan Zhang, Shuai Xu, Yuyang Zhu, Yimin Lai, Maode Nutrients Article Copy number variants (CNVs) have been implicated as an important genetic marker of obesity, and gene-environment interaction has been found to modulate risk of obesity. To evaluate the associations between CNVs and childhood obesity, as well as the interactions between CNVs and dietary behaviors, we recruited 534 obese children and 508 controls from six cities in China and six candidate CNVs were screened through published genome-wide studies (GWAS) on childhood obesity. We found three loci (10q11.22, 4q25 and 11q11) to be significantly associated with obesity after false discovery rate (FDR) correction (all the p ≤ 0.05). Cumulative effect of the three positive loci was measured by the genetic risk score (GRS), showing a significant relationship with the risk of obesity (P(trend) < 0.001). The OR of obesity increased to 21.38 (95% CI = 21.19–21.55) among the 10q11.22 deletion carriers who had meat-based diets, indicating prominent multiplicative interaction (MI) between deletions of 10q11.22 and preference for a meat-based diet. Simultaneous deletions of 5q13.2 and duplications of 6q14.1 had significant MI with a preference for salty foods. Our results suggested that CNVs may contribute to the genetic susceptibility of childhood obesity, and the CNV-diet interactions modulate the risk of obesity. MDPI 2015-04-22 /pmc/articles/PMC4425189/ /pubmed/25912042 http://dx.doi.org/10.3390/nu7043054 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Dandan
Li, Zhenli
Wang, Hao
Yang, Min
Liang, Li
Fu, Junfen
Wang, Chunling
Ling, Jie
Zhang, Yan
Zhang, Shuai
Xu, Yuyang
Zhu, Yimin
Lai, Maode
Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title_full Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title_fullStr Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title_full_unstemmed Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title_short Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity
title_sort interactions between obesity-related copy number variants and dietary behaviors in childhood obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425189/
https://www.ncbi.nlm.nih.gov/pubmed/25912042
http://dx.doi.org/10.3390/nu7043054
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