NODding off AKI with Progranulin?

Inflammation is a common feature of murine models of AKI. The endogenous mechanisms which serve to limit inflammation and reduce the severity of AKI are poorly understood. Zhou et al identify progranulin as one such protective mediator. Deficiency of progranulin was associated with increased inflamm...

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Detalles Bibliográficos
Autores principales: Tadagavadi, Raghu K., Reeves, W. Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425217/
https://www.ncbi.nlm.nih.gov/pubmed/25951064
http://dx.doi.org/10.1038/ki.2015.14
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author Tadagavadi, Raghu K.
Reeves, W. Brian
author_facet Tadagavadi, Raghu K.
Reeves, W. Brian
author_sort Tadagavadi, Raghu K.
collection PubMed
description Inflammation is a common feature of murine models of AKI. The endogenous mechanisms which serve to limit inflammation and reduce the severity of AKI are poorly understood. Zhou et al identify progranulin as one such protective mediator. Deficiency of progranulin was associated with increased inflammation and increased injury in both ischemic and nephrotoxic models of AKI. Moreover, administration of exogenous progranulin reduced AKI even when delivered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PRGN-based therapeutics are under development and might have application in the treatment or prevention of AKI.
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spelling pubmed-44252172015-11-01 NODding off AKI with Progranulin? Tadagavadi, Raghu K. Reeves, W. Brian Kidney Int Article Inflammation is a common feature of murine models of AKI. The endogenous mechanisms which serve to limit inflammation and reduce the severity of AKI are poorly understood. Zhou et al identify progranulin as one such protective mediator. Deficiency of progranulin was associated with increased inflammation and increased injury in both ischemic and nephrotoxic models of AKI. Moreover, administration of exogenous progranulin reduced AKI even when delivered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PRGN-based therapeutics are under development and might have application in the treatment or prevention of AKI. 2015-05 /pmc/articles/PMC4425217/ /pubmed/25951064 http://dx.doi.org/10.1038/ki.2015.14 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Tadagavadi, Raghu K.
Reeves, W. Brian
NODding off AKI with Progranulin?
title NODding off AKI with Progranulin?
title_full NODding off AKI with Progranulin?
title_fullStr NODding off AKI with Progranulin?
title_full_unstemmed NODding off AKI with Progranulin?
title_short NODding off AKI with Progranulin?
title_sort nodding off aki with progranulin?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425217/
https://www.ncbi.nlm.nih.gov/pubmed/25951064
http://dx.doi.org/10.1038/ki.2015.14
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