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Delivery as nanoparticles reduces imatinib mesylate-induced cardiotoxicity and improves anticancer activity

Clinical effectiveness of imatinib mesylate in cancer treatment is compromised by its off-target cardiotoxicity. In the present study, we have developed physically stable imatinib mesylate-loaded poly(lactide-co-glycolide) nanoparticles (INPs) that could sustainably release the drug, and studied its...

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Detalles Bibliográficos
Autores principales:	Marslin, Gregory, Revina, Ann Mary, Khandelwal, Vinoth Kumar Megraj, Balakumar, Krishnamoorthy, Prakash, Jose, Franklin, Gregory, Sheeba, Caroline J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425327/ https://www.ncbi.nlm.nih.gov/pubmed/25995626 http://dx.doi.org/10.2147/IJN.S75962

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