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GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review
Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in People’s Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425336/ https://www.ncbi.nlm.nih.gov/pubmed/25995643 http://dx.doi.org/10.2147/OTT.S79099 |
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author | Zhang, Xi-Liang Cui, Yong-Hui |
author_facet | Zhang, Xi-Liang Cui, Yong-Hui |
author_sort | Zhang, Xi-Liang |
collection | PubMed |
description | Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in People’s Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28–1.69) was found between the null GSTM1 and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1 may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene–gene and gene–environment interactions are required for definite conclusions. |
format | Online Article Text |
id | pubmed-4425336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44253362015-05-20 GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review Zhang, Xi-Liang Cui, Yong-Hui Onco Targets Ther Original Research Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in People’s Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28–1.69) was found between the null GSTM1 and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1 may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene–gene and gene–environment interactions are required for definite conclusions. Dove Medical Press 2015-04-28 /pmc/articles/PMC4425336/ /pubmed/25995643 http://dx.doi.org/10.2147/OTT.S79099 Text en © 2015 Zhang and Cui. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhang, Xi-Liang Cui, Yong-Hui GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title | GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title_full | GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title_fullStr | GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title_full_unstemmed | GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title_short | GSTM1 null genotype and gastric cancer risk in the Chinese population: an updated meta-analysis and review |
title_sort | gstm1 null genotype and gastric cancer risk in the chinese population: an updated meta-analysis and review |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425336/ https://www.ncbi.nlm.nih.gov/pubmed/25995643 http://dx.doi.org/10.2147/OTT.S79099 |
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