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Doxorubicin Impairs the Insulin-Like Growth Factor-1 System and Causes Insulin-Like Growth Factor-1 Resistance in Cardiomyocytes

BACKGROUND: Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R. Since cardiomyocyte apoptosis is implicat...

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Detalles Bibliográficos
Autores principales:	Fabbi, Patrizia, Spallarossa, Paolo, Garibaldi, Silvano, Barisione, Chiara, Mura, Marzia, Altieri, Paola, Rebesco, Barbara, Monti, Maria Gaia, Canepa, Marco, Ghigliotti, Giorgio, Brunelli, Claudio, Ameri, Pietro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425434/ https://www.ncbi.nlm.nih.gov/pubmed/25955698 http://dx.doi.org/10.1371/journal.pone.0124643

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