Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

A common key regulator of oncogenic signaling pathways in multiple tumor types is the unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and potency. Using mechanism-based screening, here we find that all-trans retinoic acid (ATRA)--a therapy for acute promyelocy...

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Detalles Bibliográficos
Autores principales: Wei, Shuo, Kozono, Shingo, Kats, Lev, Nechama, Morris, Li, Wenzong, Guarnerio, Jlenia, Luo, Manli, You, Mi-Hyeon, Yao, Yandan, Kondo, Asami, Hu, Hai, Bozkurt, Gunes, Moerke, Nathan J., Cao, Shugeng, Reschke, Markus, Chen, Chun-Hau, Rego, Eduardo M., LoCoco, Francesco, Cantley, Lewis, Lee, Tae Ho, Wu, Hao, Zhang, Yan, Pandolfi, Pier Paolo, Zhou, Xiao Zhen, Lu, Kun Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425616/
https://www.ncbi.nlm.nih.gov/pubmed/25849135
http://dx.doi.org/10.1038/nm.3839

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