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Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine
One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425620/ https://www.ncbi.nlm.nih.gov/pubmed/25961069 http://dx.doi.org/10.1016/j.gendis.2014.12.004 |
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author | Maxhimer, Justin B. Bradley, James P. Lee, Justine C. |
author_facet | Maxhimer, Justin B. Bradley, James P. Lee, Justine C. |
author_sort | Maxhimer, Justin B. |
collection | PubMed |
description | One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis. This work has translated to methods and advances in bone tissue engineering. In this review, we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine. |
format | Online Article Text |
id | pubmed-4425620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-44256202015-05-08 Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine Maxhimer, Justin B. Bradley, James P. Lee, Justine C. Genes Dis Article One of the simplest models for examining the interplay between bone formation and resorption is the junction between the cranial bones. Although only roughly a quarter of patients diagnosed with craniosynostosis have been linked to known genetic disturbances, the molecular mechanisms elucidated from these studies have provided basic knowledge of bone homeostasis. This work has translated to methods and advances in bone tissue engineering. In this review, we examine the current knowledge of cranial suture biology derived from human craniosynostosis syndromes and discuss its application to regenerative medicine. Chongqing Medical University 2015-01-09 /pmc/articles/PMC4425620/ /pubmed/25961069 http://dx.doi.org/10.1016/j.gendis.2014.12.004 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Maxhimer, Justin B. Bradley, James P. Lee, Justine C. Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title | Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title_full | Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title_fullStr | Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title_full_unstemmed | Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title_short | Signaling pathways in osteogenesis and osteoclastogenesis: Lessons from cranial sutures and applications to regenerative medicine |
title_sort | signaling pathways in osteogenesis and osteoclastogenesis: lessons from cranial sutures and applications to regenerative medicine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425620/ https://www.ncbi.nlm.nih.gov/pubmed/25961069 http://dx.doi.org/10.1016/j.gendis.2014.12.004 |
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