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Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells

Although many chemotherapeutic strategies against cancer have been developed, pancreatic cancer is one of the most aggressive and intractable types of malignancies. Therefore, new strategies and anti-cancer agents are necessary to treat this disease. Metformin is a widely used drug for type-2 diabet...

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Detalles Bibliográficos
Autores principales:	Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Horinaka, Mano, Sowa, Yoshihiro, Sakai, Toshiyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425682/ https://www.ncbi.nlm.nih.gov/pubmed/25955843 http://dx.doi.org/10.1371/journal.pone.0125779

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