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The need for a personalized approach for prostate cancer management

The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in met...

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Detalles Bibliográficos
Autores principales: Sedelaar, JP Michiel, Schalken, Jack A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425856/
https://www.ncbi.nlm.nih.gov/pubmed/25956920
http://dx.doi.org/10.1186/s12916-015-0344-1
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author Sedelaar, JP Michiel
Schalken, Jack A
author_facet Sedelaar, JP Michiel
Schalken, Jack A
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description The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castration-resistant prostate cancers. Up to now, we have not used individualized genetic classifiers for detailed sub-stratification, thus treating all patients as equal, and being only moderately successful. With the expected increase in systemic treatments, there is an apparent need for such classifiers. We will address these needs in this short commentary.
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spelling pubmed-44258562015-05-10 The need for a personalized approach for prostate cancer management Sedelaar, JP Michiel Schalken, Jack A BMC Med Commentary The stratification of patients for treatment of prostate cancer is based on very general parameters like prostate-specific antigen, Gleason score, and TNM classification. We use these rough parameters for selection of active surveillance, active treatment, and even for the treatment selection in metastasized or castration-resistant prostate cancers. Up to now, we have not used individualized genetic classifiers for detailed sub-stratification, thus treating all patients as equal, and being only moderately successful. With the expected increase in systemic treatments, there is an apparent need for such classifiers. We will address these needs in this short commentary. BioMed Central 2015-05-09 /pmc/articles/PMC4425856/ /pubmed/25956920 http://dx.doi.org/10.1186/s12916-015-0344-1 Text en © Sedelaar and Schalken; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Sedelaar, JP Michiel
Schalken, Jack A
The need for a personalized approach for prostate cancer management
title The need for a personalized approach for prostate cancer management
title_full The need for a personalized approach for prostate cancer management
title_fullStr The need for a personalized approach for prostate cancer management
title_full_unstemmed The need for a personalized approach for prostate cancer management
title_short The need for a personalized approach for prostate cancer management
title_sort need for a personalized approach for prostate cancer management
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425856/
https://www.ncbi.nlm.nih.gov/pubmed/25956920
http://dx.doi.org/10.1186/s12916-015-0344-1
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