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Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes

BACKGROUND: Diabetes and Nephrotic syndrome (NS) promote plaque-related gingivitis and yeast-like fungal infections. The study assesses the impact of Candida spp. and general disease- or treatment-related factors on plaque-related gingivitis severity in children and adolescents with Nephrotic syndro...

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Autores principales: Olczak-Kowalczyk, Dorota, Pyrżak, Beata, Dąbkowska, Maria, Pańczyk-Tomaszewska, Małgorzata, Miszkurka, Grażyna, Rogozińska, Izabela, Swoboda-Kopeć, Ewa, Gozdowski, Dariusz, Kalińska, Angelika, Piróg, Anna, Mizerska-Wasiak, Małgorzata, Roszkowska-Blaim, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425863/
https://www.ncbi.nlm.nih.gov/pubmed/25952029
http://dx.doi.org/10.1186/s12903-015-0042-6
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author Olczak-Kowalczyk, Dorota
Pyrżak, Beata
Dąbkowska, Maria
Pańczyk-Tomaszewska, Małgorzata
Miszkurka, Grażyna
Rogozińska, Izabela
Swoboda-Kopeć, Ewa
Gozdowski, Dariusz
Kalińska, Angelika
Piróg, Anna
Mizerska-Wasiak, Małgorzata
Roszkowska-Blaim, Maria
author_facet Olczak-Kowalczyk, Dorota
Pyrżak, Beata
Dąbkowska, Maria
Pańczyk-Tomaszewska, Małgorzata
Miszkurka, Grażyna
Rogozińska, Izabela
Swoboda-Kopeć, Ewa
Gozdowski, Dariusz
Kalińska, Angelika
Piróg, Anna
Mizerska-Wasiak, Małgorzata
Roszkowska-Blaim, Maria
author_sort Olczak-Kowalczyk, Dorota
collection PubMed
description BACKGROUND: Diabetes and Nephrotic syndrome (NS) promote plaque-related gingivitis and yeast-like fungal infections. The study assesses the impact of Candida spp. and general disease- or treatment-related factors on plaque-related gingivitis severity in children and adolescents with Nephrotic syndrome /diabetes. METHODS: Body mass index (BMI), BMI standard deviation score, and oral cavity (Plaque Index – PLI, Gingival Index – GI, mucosa status, presence and Candida enzymatic activity) were assessed in 96 patients (32 with NS: 30- immunosuppressive treatment, 35 - type 1 diabetes, and 29 generally healthy), aged; 3–18 years. Laboratory included cholesterol and triglyceride measurements; in diabetic subjects– glycated haemoglobin, in NS: total protein, albumin, creatinine, haemoglobin, haematocrit, white cell count, urinary protein excretion. Medical records supplied information on disease duration and treatment. A statistical analysis was performed; Kendall Tau coefficient, chi-square test, t-test, and multiple regression analysis ( P < 0.05). RESULTS: Candida spp. often occurred in healthy patients, but oral candidiasis was found only in the NS and diabetes groups (9.37% and 11.43%). Gingivitis occurred more frequently in patients with NS/diabetes. Gingivitis severity was correlated with PLI, age, and yeast enzyme activity in NS – to with immunosuppressive treatment with >1 drug, drug doses, treatment duration, lipid disorders, and BMI; in diabetes, with blood glucose and glycated haemoglobin >8%. CONCLUSION: Poor hygiene control is the main cause of gingivitis. Gingivitis severity is most likely related to age, lipid disorders and increase in body mass. Candida spp., in uncompensated diabetes and in those using immunosuppressive treatment, might intensify plaque-related gingivitis.
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spelling pubmed-44258632015-05-10 Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes Olczak-Kowalczyk, Dorota Pyrżak, Beata Dąbkowska, Maria Pańczyk-Tomaszewska, Małgorzata Miszkurka, Grażyna Rogozińska, Izabela Swoboda-Kopeć, Ewa Gozdowski, Dariusz Kalińska, Angelika Piróg, Anna Mizerska-Wasiak, Małgorzata Roszkowska-Blaim, Maria BMC Oral Health Research Article BACKGROUND: Diabetes and Nephrotic syndrome (NS) promote plaque-related gingivitis and yeast-like fungal infections. The study assesses the impact of Candida spp. and general disease- or treatment-related factors on plaque-related gingivitis severity in children and adolescents with Nephrotic syndrome /diabetes. METHODS: Body mass index (BMI), BMI standard deviation score, and oral cavity (Plaque Index – PLI, Gingival Index – GI, mucosa status, presence and Candida enzymatic activity) were assessed in 96 patients (32 with NS: 30- immunosuppressive treatment, 35 - type 1 diabetes, and 29 generally healthy), aged; 3–18 years. Laboratory included cholesterol and triglyceride measurements; in diabetic subjects– glycated haemoglobin, in NS: total protein, albumin, creatinine, haemoglobin, haematocrit, white cell count, urinary protein excretion. Medical records supplied information on disease duration and treatment. A statistical analysis was performed; Kendall Tau coefficient, chi-square test, t-test, and multiple regression analysis ( P < 0.05). RESULTS: Candida spp. often occurred in healthy patients, but oral candidiasis was found only in the NS and diabetes groups (9.37% and 11.43%). Gingivitis occurred more frequently in patients with NS/diabetes. Gingivitis severity was correlated with PLI, age, and yeast enzyme activity in NS – to with immunosuppressive treatment with >1 drug, drug doses, treatment duration, lipid disorders, and BMI; in diabetes, with blood glucose and glycated haemoglobin >8%. CONCLUSION: Poor hygiene control is the main cause of gingivitis. Gingivitis severity is most likely related to age, lipid disorders and increase in body mass. Candida spp., in uncompensated diabetes and in those using immunosuppressive treatment, might intensify plaque-related gingivitis. BioMed Central 2015-05-08 /pmc/articles/PMC4425863/ /pubmed/25952029 http://dx.doi.org/10.1186/s12903-015-0042-6 Text en © Olczak-Kowalczyk et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Olczak-Kowalczyk, Dorota
Pyrżak, Beata
Dąbkowska, Maria
Pańczyk-Tomaszewska, Małgorzata
Miszkurka, Grażyna
Rogozińska, Izabela
Swoboda-Kopeć, Ewa
Gozdowski, Dariusz
Kalińska, Angelika
Piróg, Anna
Mizerska-Wasiak, Małgorzata
Roszkowska-Blaim, Maria
Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title_full Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title_fullStr Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title_full_unstemmed Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title_short Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
title_sort candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425863/
https://www.ncbi.nlm.nih.gov/pubmed/25952029
http://dx.doi.org/10.1186/s12903-015-0042-6
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