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Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau

INTRODUCTION: Neurofibrillary tangles (NFT) composed of Tau are hallmarks of neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro-aggregant human Tau (2N4R Tau-ΔK280, termed Tau(ΔK)) or its repeat domain (TauRD-ΔK280, TauRD(ΔK)) develop a progressive Tau pathology with...

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Detalles Bibliográficos
Autores principales:	Hochgräfe, Katja, Sydow, Astrid, Matenia, Dorthe, Cadinu, Daniela, Könen, Stefanie, Petrova, Olga, Pickhardt, Marcus, Goll, Petra, Morellini, Fabio, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425867/ https://www.ncbi.nlm.nih.gov/pubmed/25958115 http://dx.doi.org/10.1186/s40478-015-0204-4

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