Detecting non-allelic homologous recombination from high-throughput sequencing data

Non-allelic homologous recombination (NAHR) is a common mechanism for generating genome rearrangements and is implicated in numerous genetic disorders, but its detection in high-throughput sequencing data poses a serious challenge. We present a probabilistic model of NAHR and demonstrate its ability...

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Detalles Bibliográficos
Autores principales: Parks, Matthew M, Lawrence, Charles E, Raphael, Benjamin J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425883/
https://www.ncbi.nlm.nih.gov/pubmed/25886137
http://dx.doi.org/10.1186/s13059-015-0633-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425883/
https://www.ncbi.nlm.nih.gov/pubmed/25886137
http://dx.doi.org/10.1186/s13059-015-0633-1

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