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Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

BACKGROUND: Marine microorganisms are an important source of new drug leads. However, the discovery and sustainable production of these compounds are often hampered due to the unavailable expression of cryptic biosynthetic gene clusters or limited titer. Ribosome engineering and response surface met...

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Detalles Bibliográficos
Autores principales:	Zhang, Yonghe, Huang, Huiming, Xu, Shanshan, Wang, Bo, Ju, Jianhua, Tan, Huarong, Li, Wenli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425903/ https://www.ncbi.nlm.nih.gov/pubmed/25927229 http://dx.doi.org/10.1186/s12934-015-0244-2

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