High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California

We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitte...

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Autores principales: Hollingsworth, T. Déirdre, Pilcher, Christopher D., Hecht, Frederick M., Deeks, Steven G., Fraser, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425938/
https://www.ncbi.nlm.nih.gov/pubmed/25542958
http://dx.doi.org/10.1093/infdis/jiu831
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author Hollingsworth, T. Déirdre
Pilcher, Christopher D.
Hecht, Frederick M.
Deeks, Steven G.
Fraser, Christophe
author_facet Hollingsworth, T. Déirdre
Pilcher, Christopher D.
Hecht, Frederick M.
Deeks, Steven G.
Fraser, Christophe
author_sort Hollingsworth, T. Déirdre
collection PubMed
description We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships.
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spelling pubmed-44259382015-05-15 High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California Hollingsworth, T. Déirdre Pilcher, Christopher D. Hecht, Frederick M. Deeks, Steven G. Fraser, Christophe J Infect Dis Major Articles and Brief Reports We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships. Oxford University Press 2015-06-01 2014-12-26 /pmc/articles/PMC4425938/ /pubmed/25542958 http://dx.doi.org/10.1093/infdis/jiu831 Text en © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Hollingsworth, T. Déirdre
Pilcher, Christopher D.
Hecht, Frederick M.
Deeks, Steven G.
Fraser, Christophe
High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title_full High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title_fullStr High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title_full_unstemmed High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title_short High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
title_sort high transmissibility during early hiv infection among men who have sex with men—san francisco, california
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425938/
https://www.ncbi.nlm.nih.gov/pubmed/25542958
http://dx.doi.org/10.1093/infdis/jiu831
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