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Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells

Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of...

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Autores principales: Masuda, Shinya, Hisamatsu, Tsubasa, Seko, Daiki, Urata, Yoshishige, Goto, Shinji, Li, Tao-Sheng, Ono, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425979/
https://www.ncbi.nlm.nih.gov/pubmed/25869487
http://dx.doi.org/10.14814/phy2.12377
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author Masuda, Shinya
Hisamatsu, Tsubasa
Seko, Daiki
Urata, Yoshishige
Goto, Shinji
Li, Tao-Sheng
Ono, Yusuke
author_facet Masuda, Shinya
Hisamatsu, Tsubasa
Seko, Daiki
Urata, Yoshishige
Goto, Shinji
Li, Tao-Sheng
Ono, Yusuke
author_sort Masuda, Shinya
collection PubMed
description Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total-body γ-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to γ-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice.
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spelling pubmed-44259792015-05-14 Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells Masuda, Shinya Hisamatsu, Tsubasa Seko, Daiki Urata, Yoshishige Goto, Shinji Li, Tao-Sheng Ono, Yusuke Physiol Rep Original Research Exposure to high levels of genotoxic stress, such as high-dose ionizing radiation, increases both cancer and noncancer risks. However, it remains debatable whether low-dose ionizing radiation reduces cellular function, or rather induces hormetic health benefits. Here, we investigated the effects of total-body γ-ray radiation on muscle stem cells, called satellite cells. Adult C57BL/6 mice were exposed to γ-radiation at low- to high-dose rates (low, 2 or 10 mGy/day; moderate, 50 mGy/day; high, 250 mGy/day) for 30 days. No hormetic responses in proliferation, differentiation, or self-renewal of satellite cells were observed in low-dose radiation-exposed mice at the acute phase. However, at the chronic phase, population expansion of satellite cell-derived progeny was slightly decreased in mice exposed to low-dose radiation. Taken together, low-dose ionizing irradiation may suppress satellite cell function, rather than induce hormetic health benefits, in skeletal muscle in adult mice. BlackWell Publishing Ltd 2015-04-13 /pmc/articles/PMC4425979/ /pubmed/25869487 http://dx.doi.org/10.14814/phy2.12377 Text en © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Masuda, Shinya
Hisamatsu, Tsubasa
Seko, Daiki
Urata, Yoshishige
Goto, Shinji
Li, Tao-Sheng
Ono, Yusuke
Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title_full Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title_fullStr Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title_full_unstemmed Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title_short Time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
title_sort time- and dose-dependent effects of total-body ionizing radiation on muscle stem cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425979/
https://www.ncbi.nlm.nih.gov/pubmed/25869487
http://dx.doi.org/10.14814/phy2.12377
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